Korean J Pancreas Biliary Tract.  2016 Jul;21(3):144-149. 10.15279/kpba.2016.21.3.144.

Undifferentiated Carcinoma of the Pancreas with Osteoclast-Like Giant Cells: Initially Diagnosed as Solid Pseudopapillary Tumor

  • 1Departments of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. isle@catholic.ac.kr


Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCPOGC) is a rare, highly malignant pancreatic exocrine neoplasm. Here, we report a case of UCPOGC in a 58-year-old man who presented with abdominal pain and weight loss. Abdomen computed tomography (CT) revealed a 5cm sized pancreatic body mass with peripheral enhancement. Endoscopic ultrasound (EUS)-guided biopsy of the mass suggested a solid-pseudopapillary tumor of the pancreas with a marked degenerative change. Distal pancreatectomy and splenectomy were performed. The size of the mass was 5.4 × 4.8 cm and the cut surface showed necrosis and hemorrhage. A definite diagnosis of UCPOGC was made using the histopathology and immunohistochemical findings.


Carcinoma; Undifferentiated; Osteoclast; Giant cells; Pancreas
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