J Korean Surg Soc.  2011 Aug;81(2):146-150. 10.4174/jkss.2011.81.2.146.

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells

Affiliations
  • 1Division of Hepatico Biliary Pancreatic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea. chcho@jnu.ac.kr
  • 2Department of Surgery, Mokpo Christian Hospital, Mokpo, Korea.
  • 3Department of Radiology, Chonnam National University Medical School, Gwangju, Korea.
  • 4Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.

Abstract

Undifferentiated carcinoma with osteoclast-like giant cells is a rare neoplasm of the exocrine pancreas. Some similar cases have been reported, but the histogenesis of these tumors varies and is controversial. We report here on a case of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells. A 77-year old woman presented with abdominal pain and anorexia. Abdominal computed tomography and magnetic resonance imaging showed an approximately 10 x 5 cm highly attenuated mass arising from the tail of the pancreas and invading the spleen and adjacent bowel loop. The initial impression was a malignant endocrine tumor or solid-pseudopapillary tumor of the pancreas. The patient underwent a distal pancreatectomy with splenectomy and left hemicolectomy. The histopathology and immunohistochemistry helped make the diagnosis that of an undifferentiated carcinoma with osteoclast-like giant cells of the pancreas.

Keyword

Osteoclast-like giant cells; Undifferentiated carcinoma; Pancreas

MeSH Terms

Abdominal Pain
Anorexia
Carcinoma
Female
Giant Cells
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Pancreas
Pancreas, Exocrine
Pancreatectomy
Spleen
Splenectomy
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