Infect Chemother.
2016 Dec;48(4):257-266. 10.3947/ic.2016.48.4.257.
Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease
- Affiliations
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- 1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 2Division of Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA. nahm@uab.edu
- KMID: 2441319
- DOI: http://doi.org/10.3947/ic.2016.48.4.257
Abstract
- The pneumococcal conjugate vaccine (PCV) was developed to overcome the limitations of the pneumococcal polysaccharide vaccine, which produces poor immunogenicity in infants younger than 2 years. As many countries have included PCVs in national immunization programs for children, the incidence of invasive pneumococcal disease caused by vaccine type Streptococcus pneumoniae has declined markedly, not only among the vaccinated pediatric population, but also among unvaccinated adults. In this review, we present a concise overview of the indirect effects of mass pediatric PCV immunization on unvaccinated adults.
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