J Korean Neurol Assoc.
2018 May;36(2):116-118. 10.17340/jkna.2018.2.13.
Metronidazole-Induced Encephalopathy with Thiamine Deficiency
- Affiliations
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- 1Department of Neurology, Dong-A University, College of Medicine, Busan, Korea. jhjeong@dau.ac.kr
- 2Department of Intensive Care Medicine, Dong-A University, College of Medicine, Busan, Korea.
- KMID: 2436112
- DOI: http://doi.org/10.17340/jkna.2018.2.13
Abstract
- Metronidazole-induced encephalopathy (MIE) can be caused by excessive dose or prolonged metronidazole administration. The signal abnormalities in the cerebellar dentate nuclei, midbrain, dorsal pons and corpus callosum on magnetic resonance imaging are considered as the characteristic feature of MIE. Although the mechanism of MIE remains to be elucidated, various hypothesis have been proposed including the role of metronidazole as a thiamine antagonist. Here we report a 58-year-old woman with MIE who coincidentally presented with thiamine deficiency.
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