Korean J Radiol.  2017 Oct;18(5):763-772. 10.3348/kjr.2017.18.5.763.

High-Pitch Coronary CT Angiography at 70 kVp Adopting a Protocol of Low Injection Speed and Low Volume of Contrast Medium

Affiliations
  • 1Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang 110001, P.R. China. 270973226@163.com
  • 2Department of Radiology, Hebei General Hospital, Shijiazhuang 050051, P.R. China.

Abstract


OBJECTIVE
To evaluate the feasibility and image quality (IQ) of prospectively high-pitch coronary CT angiography (CCTA) with low contrast medium injection rate at 70 kVp.
MATERIALS AND METHODS
One hundred and four patients with suspected coronary artery disease (body mass index < 26 kg/m², sinus rhythm and heart rate < 70 beats/min) were prospectively enrolled and randomly divided into two groups. In group A and group B, 28 mL and 40 mL of 370 mgI/mL iodinated contrast media was administrated at a flow rate of 3.5 and 5 mL/s, respectively. CT values, noise, signal-to-noise ratio, contrast-to-noise ratio (CNR) of the proximal segments of coronary arteries and subjective IQ were evaluated.
RESULTS
The CT values and noise in group A were significantly lower than those in group B (434-485 Hounsfield units [HU] vs. 772-851 HU, all p < 0.001; 17.8-22.3 vs. 23.3-26.4, all p < 0.005). The CNRs of the right coronary artery and left main artery showed no statistical difference between the two groups (42.1 ± 13.8 vs. 36.8 ± 16.0, p = 0.074; 38.7 ± 10.6 vs. 38.1 ± 17.0, p = 0.819). No statistical difference was observed between the two groups in IQ scores (3.04 ± 0.75 vs. 3.0 ± 0.79, p = 0.526) and diagnostic ratio (96.1% [50/52] vs. 94.2% [49/52], p = 0.647).
CONCLUSION
Prospective high-pitch CCTA at 70 kVp with 28 mL of contrast media and injection rate of 3.5 mL/s could provide diagnostic IQ for normal-weight patients with heart rate of < 70 beats/min.

Keyword

Low tube voltage; Contrast medium; Coronary CT angiography; Iodine delivery rate; CT attenuation enhancement; Radiation reduction; Low dose contrast agent

MeSH Terms

Adult
Aged
Aged, 80 and over
Body Mass Index
*Computed Tomography Angiography
Contrast Media/*chemistry
Coronary Artery Disease/*diagnosis/diagnostic imaging
Female
Heart Rate
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Prospective Studies
Signal-To-Noise Ratio
Contrast Media
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