Intest Res.  2017 Apr;15(2):221-227. 10.5217/ir.2017.15.2.221.

Clinical outcome of endoscopic management in delayed postpolypectomy bleeding

• Lee JM
• Kim WS
• Kwak MS
• Hwang SW
• Yang DH
• Myung SJ
• Yang SK
• Byeon JS

• KMID: 2425165
• DOI: http://doi.org/10.5217/ir.2017.15.2.221

Abstract

BACKGROUND/AIMS
The clinical course after endoscopic management of delayed postpolypectomy bleeding (DPPB) has not been clearly determined. This study aimed to assess clinical outcomes after endoscopic hemostasis of DPPB and evaluate risk factors for rebleeding after initial hemostasis.
METHODS
We reviewed medical records of 198 patients who developed DPPB and underwent endoscopic hemostasis between January 2010 and February 2015. The performance of endoscopic hemostasis was assessed. Rebleeding negative and positive patients were compared.
RESULTS
DPPB developed 1.4±1.6 days after colonoscopic polypectomy. All patients achieved initial hemostasis. Clipping was the most commonly used technique. Of 198 DPPB patients, 15 (7.6%) had rebleeding 3.3±2.5 days after initial hemostasis. The number of clips required for hemostasis was higher in the rebleeding positive group (3.2±1.6 vs. 4.2±1.9, P=0.047). Combinations of clipping with other modalities such as injection methods were more common in the rebleeding positive group (67/291, 23.0% vs. 12/17, 70.6%; P<0.001). Multivariate analysis showed a large number of clips and combination therapy were independent risk factors for rebleeding. All the rebleeding cases were successfully managed by repeat endoscopic hemostasis.
CONCLUSIONS
Endoscopic hemostasis is effective for the management of DPPB because of its high initial hemostasis rate and low rebleeding rate. Endoscopists should carefully observe patients in whom a large number of clips and/or combination therapy have been used to manage DPPB because these may be related to the severity of DPPB and a higher risk of rebleeding.

Keyword

Colonoscopy; Postpolypectomy bleeding; Clip; Rebleeding

MeSH Terms

Colonoscopy
Hemorrhage*
Hemostasis
Hemostasis, Endoscopic
Humans
Medical Records
Multivariate Analysis
Risk Factors

Figure

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  Fig. 1 Flow diagram of patients with delayed postpolypectomy bleeding (DPPB). All DPPB patients were eventually managed by endoscopic hemostasis.

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  Fig. 2 Rebleeding after initial endoscopic hemostasis in delayed postpolypectomy bleeding (DPPB). (A) Active blood oozing is noted at a large postpolypectomy ulcer where five clips were applied during a previous endoscopy to control DPPB. All five clips were attached at the periphery of the ulcer. (B) Hemostasis was achieved by the application of additional argon plasma A B coagulation.

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