Genomics Inform.  2018 Sep;16(3):71-74. 10.5808/GI.2018.16.3.71.

Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer

Affiliations
  • 1Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea. kimsy@kribb.re.kr
  • 2Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • 3Department of Urology, Chungbuk National University College of Medicine, Cheongju 28644, Korea.
  • 4Department of Urology, Chungbuk National University Hospital, Cheongju 28644, Korea.
  • 5Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea.

Abstract

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

Keyword

castration-resistant prostate cancer; DNA variants; whole-genome sequencing
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