Korean J Urol Oncol.
2020 Apr;18(1):18-23. 10.22465/kjuo.2020.18.1.18.
Next-Generation Sequencing in Prostate Cancer
- Affiliations
-
- 1Department of Urology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea
- KMID: 2502096
- DOI: http://doi.org/10.22465/kjuo.2020.18.1.18
Abstract
- Prostate cancer is one of the most common cancer worldwide, androgen-deprivation therapy (ADT) has been the mainstream of treatment after treatment failure of localized cancer. However, despite the rapid initial response of ADT, most patients eventually progress to metastatic castration-resistant prostate cancer (mCRPC). Treatment decisions for patients with mCRPC are a very complex process, and its response is varied and difficult to predict due to individual differences. Therefore, novel biomarkers and therapeutic targets based on better understanding of molecular landscape of prostate cancer are needed. In this review, we summarized the genomic information, informative biomarkers and potential molecular targets using next-generation sequencing technology of prostate cancer. (Korean J Urol Oncol 2020;18:18-23)
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Utility of Next-Generation Sequencing for Deciphering Intratumor Heterogeneity in Prostate Cancer
- The human gastrointestinal microbiota and prostate cancer development and treatment
- Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
- The course forward: next generation sequencing as part of the next generation management of patients with locally advanced cervical cancer
- Guidelines for Genetic Counseling and Reporting of Cancer Genetic Test Results: Genetic Test for Hereditary Cancer-predisposing Syndrome Using Next-generation Sequencing
