Tissue Eng Regen Med.  2018 Oct;15(5):575-590. 10.1007/s13770-018-0159-1.

Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications

• Sontyana A
• Mathew AP
• Cho KH
• Uthaman S
• Park IK

• KMID: 2422672
• DOI: http://doi.org/10.1007/s13770-018-0159-1

Abstract

BACKGROUND
Biopolymeric in situ hydrogels play a crucial role in the regenerative repair and replacement of infected or injured tissue. They possess excellent biodegradability and biocompatibility in the biological system, however only a few biopolymeric in situ hydrogels have been approved clinically. Researchers have been investigating new advancements and designs to restore tissue functions and structure, and these studies involve a composite of biometrics, cells and a combination of factors that can repair or regenerate damaged tissue.
METHODS
Injectable hydrogels, cross-linking mechanisms, bioactive materials for injectable hydrogels, clinically applied injectable biopolymeric hydrogels and the bioimaging applications of hydrogels were reviewed.
RESULTS
This article reviews the different types of biopolymeric injectable hydrogels, their gelation mechanisms, tissue engineering, clinical applications and their various in situ imaging techniques.
CONCLUSION
The applications of bioactive injectable hydrogels and their bioimaging are a promising area in tissue engineering and regenerative medicine. There is a high demand for injectable hydrogels for in situ imaging.

Keyword

Bioimaging; Biopolymeric injectable hydrogels; Gelation

MeSH Terms

Biopolymers*
Hydrogel*
Hydrogels*
Regenerative Medicine
Tissue Engineering*
Biopolymers
Hydrogel
Hydrogels