Obstet Gynecol Sci.  2018 May;61(3):359-366. 10.5468/ogs.2018.61.3.359.

Impact of presence of antiphospholipid antibodies on in vitro fertilization outcome

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. blasto@snubh.org
  • 3Department of Obstetrics and Gynecology, Seoul Maria Fertility Hospital, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract


OBJECTIVE
To investigate prevalence of antiphospholipid antibody (APA) in Korean infertile women undergoing the first in vitro fertilization (IVF) treatment and to evaluate the influence of APA on the subsequent IVF outcomes. METHOD: Two hundred nineteen infertile women who destined the first IVF were prospectively enrolled in 2 infertility centers. Male factor or uterine factor infertility and women with past or current endocrine or immunologic disorders were completely excluded. Plasma concentration of lupus anticoagulant was measured by clot-based method, and anticardiolipin antibody (IgG/IgM), and anti-β2-glycoprotein 1 antibody (IgG/IgM) was measured by enzyme-linked immunosorbent assay method before starting ovarian stimulation for IVF.
RESULTS
APA was positive in 13 women (5.9%). Lupus anticoagulant was positive in 2 women (0.9%), anticardiolipin antibody was positive in 7 women (3.2%), and anti-β2-glycoprotein 1 antibody was positive in 4 women (1.8%). In 193 women entering embryo transfer, clinical characteristics and stimulation outcomes were comparable between APA-positive (n=12) and APA-negative group (n=181). The clinical pregnancy rate (66.7% vs. 45.9%), ongoing pregnancy rate (58.3% vs. 37.0%), and miscarriage rate (12.5% vs. 19.3%) were all similar between APA-positive and APA-negative group.
CONCLUSION
The prevalence of APA is low in Korean infertile women undergoing the first IVF cycle, and the presence of APA appears to neither decrease their first IVF success nor increase abortion rate.

Keyword

Antiphospholipid antibody; In vitro fertilization; Infertility

MeSH Terms

Abortion, Induced
Abortion, Spontaneous
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid*
Embryo Transfer
Enzyme-Linked Immunosorbent Assay
Female
Fertilization in Vitro*
Humans
In Vitro Techniques*
Infertility
Lupus Coagulation Inhibitor
Male
Methods
Ovulation Induction
Plasma
Pregnancy
Pregnancy Rate
Prevalence
Prospective Studies
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Lupus Coagulation Inhibitor

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