Ann Hepatobiliary Pancreat Surg.  2018 May;22(2):150-155. 10.14701/ahbps.2018.22.2.150.

A huge intraductal papillary neoplasm of the bile duct treated by right trisectionectomy after right portal vein embolization

Affiliations
  • 1Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kent@kuhp.kyoto-u.ac.jp
  • 2Department of Surgery, Mansoura University, Mansoura, Egypt.

Abstract

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and recognized precursor of invasive carcinoma. IPNB was detected incidentally in a 60-year-old woman during check up. Radiologic images revealed a huge cystic mass with papillary projection and markedly dilated bile ducts. Biopsies revealed high-grade IPNB. Cholangioscopy detected a connection between the right posterior bile duct and cyst lumen with epithelial dysplasia of the bile duct. Right posterior sectional duct opened in the left hepatic duct. Consequently, right trisectionectomy and extrahepatic bile duct resection were conducted. Histological studies revealed intraductal papillary neoplasm with high-grade intraepithelial neoplasia (carcinoma in situ). IPNB patients without distant metastases are candidates for surgery and complete resection should be conducted to achieve long-term survival.

Keyword

Intraductal papillary neoplasm of the bile duct; Portal vein embolization; Right trisectionectomy

MeSH Terms

Bile Ducts*
Bile Ducts, Extrahepatic
Bile*
Biopsy
Female
Hepatic Duct, Common
Humans
Middle Aged
Neoplasm Metastasis
Portal Vein*

Figure

  • Fig. 1 Preoperatoive imaging findings. (A) Abdominal ultrasonography (US) revealed multiple hyper-echoic solid lesions (arrows). (B) Enhanced computed tomography (CT) revealed a huge (10×7 cm) cystic tumor with surrounding high-density components (arrows) involving the right hemiliver and the left medial section.

  • Fig. 2 Non-enhanced magnetic resonance imaging (A) revealed huge solid mass in the right hemiliver and the left medial segment of the liver. Bile ducts were markly dilated. Suspicious communication between right posterior bile duct (arrow) and the cystic lesion. Magnetic resonance cholangiography (B) revealed a marked aneurysmal dilatation of the bile duct.

  • Fig. 3 Endoscopic retrograde cholangiogram revealed communication between the proximal right hepatic duct and cyst.

  • Fig. 4 Peroral cholangioscopy findings. Papilla Vater canulation (A). No abnormal finding on hepatic hilum (B). Tumor invading the right posterior bile duct (C). Biliary papillomatosis inside of the cyst (D).

  • Fig. 5 Positron emission tomography-computed tomography scan revealed tumorous lesions with abnormal uptake and marginal dominance of FDG accumulation in the right lobe. Intrahepatic and extrahepatic metastasis were not detected.

  • Fig. 6 Three-dimensional computed tomography image before percutaneous transhepatic portal vein embolization.

  • Fig. 7 Right portal vein embolization.

  • Fig. 8 Sagittal computed tomography before (A) and after (B) percutaneous transhepatic portal vein embolization.

  • Fig. 9 Microscopic finding showing prominent papillary proliferation with fibrovascular cores.

  • Fig. 10 Gross appearance of the resected section. (A) Well defined cystic mass with multiple polypoid mural nodules (black arrows). Communication between the right posterior bile duct and the cyst cavity (yellow arrow). (B) Segment II and III bile ducts stump (B2 and B3, yellow arrows).


Reference

1. Shibahara H, Tamada S, Goto M, Oda K, Nagino M, Nagasaka T, et al. Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am J Surg Pathol. 2004; 28:327–338. PMID: 15104295.
2. Nakanuma Y, Curabo MP, Franceschi S, Gores G, Paradis V, Sripa B. WHO classification of tumours of the digestive system. Lyon: IARC;2010. p. 217–224.
3. Ohtsuka M, Shimizu H, Kato A, Yoshitomi H, Furukawa K, Tsuyuguchi T, et al. Intraductal papillary neoplasms of the bile duct. Int J Hepatol. 2014; 2014:459091. PMID: 24949206.
Article
4. Barton JG, Barrett DA, Maricevich MA, Schnelldorfer T, Wood CM, Smyrk TC, et al. Intraductal papillary mucinous neoplasm of the biliary tract: a real disease? HPB (Oxford). 2009; 11:684–691. PMID: 20495637.
Article
5. Kim KM, Lee JK, Shin JU, Lee KH, Lee KT, Sung JY, et al. Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype. Am J Gastroenterol. 2012; 107:118–125. PMID: 21946282.
Article
6. Aoki S, Okayama Y, Kitajima Y, Hayashi K, Imai H, Okamoto T, et al. Intrahepatic biliary papilloma morphologically similar to biliary cystadenoma. J Gastroenterol Hepatol. 2005; 20:321–324. PMID: 15683443.
Article
7. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC;2010. p. 3–8.
8. Zen Y, Fujii T, Itatsu K, Nakamura K, Minato H, Kasashima S, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 2006; 44:1333–1343. PMID: 17058219.
Article
9. Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, et al. Intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 2013; 19:8595–8604. PMID: 24379576.
Article
10. Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, et al. Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion. Am J Surg Pathol. 2011; 35:512–521. PMID: 21412069.
Article
11. Tan Y, Milikowski C, Toribio Y, Singer A, Rojas CP, Garcia-Buitrago MT. Intraductal papillary neoplasm of the bile ducts: a case report and literature review. World J Gastroenterol. 2015; 21:12498–12504. PMID: 26604656.
Article
12. Lee SS, Kim MH, Lee SK, Jang SJ, Song MH, Kim KP, et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004; 100:783–793. PMID: 14770435.
Article
13. Yoon KH, Ha HK, Kim CG, Roh BS, Yun KJ, Chae KM, et al. Malignant papillary neoplasms of the intrahepatic bile ducts: CT and histopathologic features. AJR Am J Roentgenol. 2000; 175:1135–1139. PMID: 11000178.
14. Sakai Y, Tsuyuguchi T, Ishihara T, Sugiyama H, Miyakawa K, Yasui S, et al. Usefulness of peroral cholangioscopy in preoperative diagnosis of intraductal papillary neoplasm of the bile duct. Hepatogastroenterology. 2010; 57:691–693. PMID: 21033211.
15. Schlitter AM, Born D, Bettstetter M, Specht K, Kim-Fuchs C, Riener MO, et al. Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. Mod Pathol. 2014; 27:73–86. PMID: 23828315.
Article
16. Paik KY, Heo JS, Choi SH, Choi DW. Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases. J Surg Oncol. 2008; 97:508–512. PMID: 18314868.
Article
17. Hokuto D, Nomi T, Yasuda S, Yoshikawa T, Ishioka K, Yamada T, et al. Long-term observation and treatment of a widespread intraductal papillary neoplasm of the bile duct extending from the intrapancreatic bile duct to the bilateral intrahepatic bile duct: A case report. Int J Surg Case Rep. 2017; 38:166–171. PMID: 28763696.
Article
18. Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, et al. Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci. 2014; 21:176–185. PMID: 23908126.
Article
19. Narita M, Endo B, Mizumoto Y, Matsusue R, Hata H, Yamaguchi T, et al. Multicentric recurrence of intraductal papillary neoplasms of bile duct in the remnant intrahepatic bile duct after curative resection. Int J Surg Case Rep. 2015; 12:123–127. PMID: 26070186.
Article
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