J Pathol Transl Med.  2018 Mar;52(2):121-125. 10.4132/jptm.2017.08.20.

Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder

Affiliations
  • 1Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. lepetit80@hanmail.net
  • 2Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

Keyword

Carcinoma, adenosquamous; Large cell neuroendocrine carcinoma; Gallbladder; Prognosis

MeSH Terms

Adenocarcinoma
Carcinoma, Adenosquamous
Carcinoma, Neuroendocrine*
Carcinoma, Squamous Cell
Chemotherapy, Adjuvant
Cholecystectomy
Drug Therapy
Female
Follow-Up Studies
Gallbladder Neoplasms
Gallbladder*
Humans
Liver
Middle Aged
Neoplasm Metastasis
Prognosis
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