Korean J Head Neck Oncol.  2019 Nov;35(2):45-49. 10.21593/kjhno/2019.35.2.45.

A Case of Large Cell Neuroendocrine Carcinoma of the Maxillary Sinus

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea. jyb20000@hanyang.ac.kr
  • 2Department of pathology, Hanyang University College of Medicine, Seoul, Korea.


Large cell neuroendocrine carcinoma is a rare epithelial neuroendocrine malignancy and is preferentially located in gastrointestinal tract and pancreas. Cases of large cell neuroendocrine carcinoma have been reported in many other locations, including the thymus, gallbladder, prostate, larynx, salivary glands, nasopharynx, tonsil and mastoid. However, primary sinonasal large cell neuroendocrine carcinoma never have been reported in Korea. We experienced a case of primary large cell neuroendocrine carcinoma arising from left maxillary sinus recently. A 82-year-old male patient presented with nasal obstruction and epistaxis. The biopsy revealed large cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT3N0M0. The patient was treated by combined radiotherapy and chemotherapy. We report this rare case with literature review.


Large cell neuroendocrine carcinoma; Paranasal sinus
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