Endocrinol Metab.  2015 Mar;30(1):105-109. 10.3803/EnM.2015.30.1.105.

Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease

• Hwang IK
• Kim SH
• Lee U
• Chin SO
• Rhee SY
• Oh S
• Woo JT
• Kim SW
• Kim YS
• Chon S

• KMID: 2407112
• DOI: http://doi.org/10.3803/EnM.2015.30.1.105

Abstract

Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.

Keyword

HLA-DQ2; Celiac disease; Graves' disease

MeSH Terms

Asia
Celiac Disease*
Diagnosis
Diarrhea
Diet
Diet, Gluten-Free
Eating
Europe
Female
Genes, MHC Class II
Genetic Predisposition to Disease
Graves Disease*
Humans
Leukocytes
Middle Aged
Prevalence
Recurrence
Serologic Tests
Weight Loss