Cancer Res Treat.  2018 Jan;50(1):222-238. 10.4143/crt.2017.093.

Nationwide Statistical Analysis of Lymphoid Malignancies in Korea

• Lee H
• Park HJ
• Park EH
• Ju HY
• Oh CM
• Kong HJ
• Jung KW
• Park BK
• Lee E
• Eom HS
• Won YJ

• KMID: 2403492
• DOI: http://doi.org/10.4143/crt.2017.093

Abstract

PURPOSE
Regional differences in the incidence of lymphoid malignancies have been reported worldwide, but there has been no large-scale epidemiologic analysis in Korea. The aim of this study was to provide a nationwide population-based statistical analysis of Korean patients with lymphoid malignancies.
MATERIALS AND METHODS
The Korea Central Cancer Registry analyzed the incidence and survival of patients with lymphoid malignancies from the Korean National Cancer Incidence Database. Diseases were grouped by clinically relevant categories based on the 2008 World Health Organization classification.
RESULTS
Overall 65,948 lymphoid diseases were identified between 1999 and 2012. The incidence of most subtypes increased with age, except for precursor cell neoplasms. Male predominance (male:female ratio=1.28:1) was observed. In 2012, annual age-standardized incidence rates per 100,000 persons of Hodgkin's lymphoma, mature B-cell neoplasm, mature T/natural killer (NK)-cell neoplasm, and precursor cell neoplasm were 0.46, 6.60, 0.95, and 1.50, respectively, and they increased yearly from 1999. Composite Hodgkin's and non-Hodgkin's lymphomas were extremely rare. Survival improvement estimated using 5-year relative survival rate was observed in patients with Hodgkin's lymphoma (71.1%-83.0%), diffuse large B-cell lymphoma (49.5%-61.5%), plasma cell neoplasms (20.2%-36.9%), and lymphoblastic lymphoma/leukemia (41.5%-56.3%) between 1993 and 2012. However, survival rates of T/NK-cell lymphoma (excluding cutaneous T-cell lymphoma) ranged from 40.5%-43.5% during the study period. Survival rates decreased with age in most subtypes.
CONCLUSION
This report presented the subtype-specific statistical analysis of lymphoid malignancies in the Korean population, showing increasing incidences and survival rates in most subtypes.

Keyword

Epidemiology; Incidence; Survival; Hematologic neoplasms; Republic of Korea

MeSH Terms

B-Lymphocytes
Classification
Epidemiology
Hematologic Neoplasms
Humans
Incidence
Korea*
Lymphoma
Lymphoma, B-Cell
Male
Neoplasms, Plasma Cell
Republic of Korea
Survival Rate
T-Lymphocytes
World Health Organization

Figure

• 

  Fig. 1. Incident cases of lymphoid malignancies in Korea, 2012. NK, natural killer; MDS, myelodysplastic syndrome; AML, acute myeloid leukemia; MPN, myeloproliferative neoplasm. a)Include one case of composite Hodgkin’s and non-Hodgkin’s lymphoma.

• 

  Fig. 2. Incident cases of lymphoid malignancies by age group in Korea, 2012. NK, natural killer. a)All lymphoid malignancies include one case of composite Hodgkin’s and non-Hodgkin’s lymphoma.

• 

  Fig. 3. Trend in relative survival rate of lymphoid malignances between 1993 and 2012 in Korea. ICD-O-3 codes are as follows. (A) Hodgkin’s lymphoma 9659, 9650, 9661, 9662, 9651, 9663, 9664, 9665, 9667, 9652,9653, 9654, 9655. (B) Diffuse large B-cell lymphoma 9675, 9678, 9679, 9680, 96849684. (C) Multiple myeloma 9732. (D) Peripheral T-cell lymphoma, except NK/ T-cell lymphoma 9702, 9705, 9714, 9716, 9717. (E) Extranodal NK/T-cell lymphoma, nasal type 9719. (F) Lymphoblastic lymphoma 9728, 9729, 9727. (G) Acute lymphoblastic leukemia 9836, 9837, 9835. (H) All lymphoid malignancies. ICD-O-3, International Classification of Diseases for Oncology, third edition.

Reference

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