- Early diagnosis of Gaucher disease in Korean patients with unexplained splenomegaly: a multicenter observational study
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Do YR, Choi Y, Heo MH, Kim JS, Yoon Jh, Lee JH, Park JS, Sohn SK, Kim SH, Lim S, Chung JS, Jo DY, Eom HS, Kim H, Jeon SY, Won JH, Lee HJ, Shin JW, Jang JH, Yoon SS
- KMID: 2533248
- Blood Res.
- 2022 Sep;57(3):207-215.
- doi: 10.5045/br.2022.2022089
Background Gaucher disease (GD) is an autosomal recessive disorder characterized by excessive accumulation of glucosylceramide in multiple organs. This study was performed to determine the detection rate of GD in a... -
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- Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea
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Yi JH, Lee GW, Lee JH, Yoo KH, Jung CW, Kim DS, Lee JO, Eom HS, Byun JM, Koh Y, Yoon SS, Kim JS, Kong JH, Yhim HY, Yang DH, Yoon DH, Lim DH, Lee WS, Shin HJ
- KMID: 2524074
- Blood Res.
- 2021 Dec;56(4):243-251.
- doi: 10.5045/br.2021.2021102
Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack... -
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- Recent Clinical Update of Acute Myeloid Leukemia: Focus on Epigenetic Therapies
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Lee E, Koh Y, Hong J, Eom HS, Yoon SS
- KMID: 2514759
- J Korean Med Sci.
- 2021 Apr;36(13):e85.
- doi: 10.3346/jkms.2021.36.e85
Acute myeloid leukemia (AML) is a complicated disease characterized by genetic heterogeneity and simultaneous alterations in multiple genes. For decades, its only curative method has been intensive induction chemotherapy with... -
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- Current Use of Total Body Irradiation in Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation
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Jung J, Lee H, Suh YG, Eom HS, Lee E
- KMID: 2513531
- J Korean Med Sci.
- 2021 Mar;36(8):e55.
- doi: 10.3346/jkms.2021.36.e55
Total body irradiation (TBI) is included in the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT), with unique advantages such as uniform distribution over the whole body and decreased... -
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- Development of an Automated Image Analyzer for Microvessel Density Measurement in Bone Marrow Biopsies
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Chung Y, Shin S, Shim H, Sohn JY, Lee DE, Lee H, Eom HS, Kim KG, Kong SY
- KMID: 2470327
- Ann Lab Med.
- 2020 Jul;40(4):312-316.
- doi: 10.3343/alm.2020.40.4.312
Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD... -
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- Efficacy of Brentuximab Vedotin in Relapsed or RefractoryHigh-CD30–Expressing Non-Hodgkin Lymphomas:Results of a Multicenter, Open-Labeled Phase II Trial
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Kim SJ, Yoon DH, Kim JS, Kang HJ, Lee HW, Eom HS, Hong JY, Cho J, Ko YH, Huh J, Yang WI, Park WS, Lee SS, Suh C, Kim WS
- KMID: 2500323
- Cancer Res Treat.
- 2020 Apr;52(2):374-387.
- doi: 10.4143/crt.2019.198
Purpose The treatment outcome of brentuximab vedotin (BV) has not been related with CD30 expression in previous studies enrolling patients with a wide range of CD30 expression level. Thus, this study explored the... -
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- Livestock-associated methicillin-resistant Staphylococcus aureus in Korea: antimicrobial resistance and molecular characteristics of LA-MRSA strains isolated from pigs, pig farmers, and farm environment
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Back SH, Eom HS, Lee HH, Lee GY, Park KT, Yang SJ
- KMID: 2469017
- J Vet Sci.
- 2020 Jan;21(1):e2.
- doi: 10.4142/jvs.2020.21.e2
The emergence of livestock-associated (LA)-methicillin-resistant Staphylococcus aureus (MRSA) in livestock animal has become a significant zoonotic concern. In the present study, we investigated nationwide prevalence of LA-MRSA across pork production... -
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- Prevalence and characteristics of livestock-associated methicillin-susceptible Staphylococcus aureus in the pork production chain in Korea
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Eom HS, Back SH, Lee HH, Lee GY, Yang SJ
- KMID: 2464085
- J Vet Sci.
- 2019 Nov;20(6):e69.
- doi: 10.4142/jvs.2019.20.e69
The emergence and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) in livestock animals have become a worldwide public health concern. While the prevalence and genetic profiles... -
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- T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia
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Kim H, Kim IS, Chang CL, Kong SY, Lim YT, Kong SG, Cho EH, Lee EY, Shin HJ, Park HJ, Eom HS, Lee H
- KMID: 2425967
- Ann Lab Med.
- 2019 Mar;39(2):125-132.
- doi: 10.3343/alm.2019.39.2.125
BACKGROUND: Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor (TCR) rearrangement in Korean T-ALL patients by fragment analysis, examining... -
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- Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
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Choi SI, Kook MC, Hwang S, Kim YI, Lee JY, Kim CG, Choi IJ, Lee H, Eom HS, Cho SJ
- KMID: 2411673
- Gut Liver.
- 2018 May;12(3):278-287.
- doi: 10.5009/gnl17217
BACKGROUND/AIMS: Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is an uncommon disease. Bone marrow involvement is reported even in patients with only a mucosal lesion. We evaluated the prevalence... -
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- Clinical Implications of Quantitative JAK2 V617F Analysis using Droplet Digital PCR in Myeloproliferative Neoplasms
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Lee E, Lee KJ, Park H, Chung JY, Lee MN, Chang MH, Yoo J, Lee H, Kong SY, Eom HS
- KMID: 2403360
- Ann Lab Med.
- 2018 Mar;38(2):147-154.
- doi: 10.3343/alm.2018.38.2.147
BACKGROUND: JAK2 V617F is the most common mutation in myeloproliferative neoplasms (MPNs) and is a major diagnostic criterion. Mutation quantification is useful for classifying patients with MPN into subgroups and... -
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- Nationwide Statistical Analysis of Lymphoid Malignancies in Korea
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Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
- KMID: 2403492
- Cancer Res Treat.
- 2018 Jan;50(1):222-238.
- doi: 10.4143/crt.2017.093
PURPOSE: Regional differences in the incidence of lymphoid malignancies have been reported worldwide, but there has been no large-scale epidemiologic analysis in Korea. The aim of this study was to... -
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- Chromothripsis in Treatment Resistance in Multiple Myeloma
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Lee KJ, Lee KH, Yoon KA, Sohn JY, Lee E, Lee H, Eom HS, Kong SY
- KMID: 2394765
- Genomics Inform.
- 2017 Sep;15(3):87-97.
- doi: 10.5808/GI.2017.15.3.87
Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, β-2 microglobulin, and albumin. Recently, the term... -
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- Efficacy of eculizumab in paroxysmal nocturnal hemoglobinuria patients with or without aplastic anemia: prospective study of a Korean PNH cohort
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Choi CW, Jang JH, Kim JS, Jo DY, Lee JH, Kim SH, Kim YK, Won JH, Chung JS, Kim H, Lee JH, Kim MK, Eom HS, Hyun SY, Kim JA, Lee JW
- KMID: 2390983
- Blood Res.
- 2017 Sep;52(3):207-211.
- doi: 10.5045/br.2017.52.3.207
BACKGROUND: Patients with paroxysmal nocturnal hemoglobinuria (PNH) often have concurrent aplastic anemia (AA). This study aimed to determine whether eculizumab-treated patients show clinical benefit regardless of concurrent AA. METHODS: We analyzed... -
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- CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy
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Park HB, Lee JE, Oh YM, Lee SJ, Eom HS, Choi K
- KMID: 2388358
- Exp Mol Med.
- 2017 Jul;49(7):e360.
- doi: 10.1038/emm.2017.104
Donor lymphocyte infusion (DLI) followed by hematopoietic stem cell transplantation has served as an effective prevention/treatment modality against the relapse of some hematologic tumors, such as chronic myeloid leukemia (CML).... -
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- Comparison of Two Apheresis Systems of COBE and Optia for Autologous Peripheral Blood Stem Cell Collection
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Lee SN, Sohn JY, Kong JH, Eom HS, Lee H, Kong SY
- KMID: 2376790
- Ann Lab Med.
- 2017 Jul;37(4):327-330.
- doi: 10.3343/alm.2017.37.4.327
Peripheral blood stem cell (PBSC) transplantation following myeloablative therapy is a mainstay of treatment for various types of malignancies. This study aimed to evaluate the differences between the Optia MNC... -
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- A Case of Disseminated Infection with Skin Manifestation due to Non-neoformans and Non-gattii Cryptococcus in a Patient with Refractory Acute Myeloid Leukemia
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Park SS, Lee H, Park WS, Hwang SH, Choi SI, Choi MH, Lee SW, Ko EJ, Choi YJ, Eom HS
- KMID: 2383937
- Infect Chemother.
- 2017 Jun;49(2):142-145.
- doi: 10.3947/ic.2017.49.2.142
Cryptococcus spp. other than Cryptococcus neoformans or Cryptococcus gattii were previously considered saprophytes and thought to be non-pathogenic to humans. However, opportunistic infections associated with non-neoformans and non-gattii species, such... -
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- Analysis of Granulocyte Transfusions in Patients with Infections and Neutropenia: A Single Center Experience
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Lee SN, Hu Y, Eom HS, Lee H, Lee E, Kong SY
- KMID: 2368787
- Korean J Blood Transfus.
- 2016 Dec;27(3):247-256.
- doi: 10.17945/kjbt.2016.27.3.247
BACKGROUND: Granulocyte transfusion therapy has been used as supportive care for patients with prolonged neutropenia after intensive chemotherapy or peripheral blood stem cell transplantation (PBSCT). Here, we investigated clinical factors... -
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- Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP
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Kim MK, Yoon KA, Park EY, Joo J, Lee EY, Eom HS, Kong SY
- KMID: 2366437
- Genomics Inform.
- 2016 Dec;14(4):205-210.
- doi: 10.5808/GI.2016.14.4.205
Interleukin-10 (IL10) plays an important role in initiating and maintaining an appropriate immune response to non-Hodgkin lymphoma (NHL). Previous studies have revealed that the transcription of IL10 mRNA and its... -
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- Radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma: dose-volumetric analysis and its clinical implications
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Lim HW, Kim TH, Choi IJ, Kim CG, Lee JY, Cho SJ, Eom HS, Moon SH, Kim DY
- KMID: 2356115
- Radiat Oncol J.
- 2016 Sep;34(3):193-201.
- doi: 10.3857/roj.2016.01865
PURPOSE: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness... -
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