Lennox-Gastaut syndrome associated with dysgenesis of corpus callosum
- Affiliations
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- 1Department of Neurology, Center for Neurology, Fairfax, VI, USA.
- 2Department of Internal Medicine, King Faisal Specialist Hospital, Hail University, Riyadh, Kingdom of Saudi Arabia. dr.legend@hotmail.com
- 3Dow Medical College, Karachi, Pakistan.
- 4Department of Internal Medicine, King Khaled Hospital, Hail, Kingdom of Saudi Arabia.
- 5Department of Pediatrics, King Khaled Hospital, Hail, Kingdom of Saudi Arabia.
- 6Center for Rehabilitation, King Khaled Hospital, Hail, Kingdom of Saudi Arabia.
- 7Speclaist in Autism and Behavioral Disorder at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
- KMID: 2403220
- DOI: http://doi.org/10.14253/acn.2018.20.1.36
Abstract
- Lennox-Gastaut syndrome (LGS) is an electro-clinical syndrome composed of the triad of mental retardation, multiple seizure types, and the characteristic generalized slow spike-wave complexes in the electroencephalogram. In this article, we report on two patients with LGS whose brain magnetic resonance imaging showed dysgenesis of corpus callosum (CC). We discuss the role of CC in the genesis of secondary bilateral synchrony.
MeSH Terms
Figure
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Fig. 1 Electroencephalography (average montage) showed diffuse background slowing associated with prolonged bursts of high voltage rhythmic 1.5 to 2.5 per second "notched delta", occurring in all leads bilaterally and synchronously.
Fig. 2 The patient is a 4-year-oldmale with Lennox-Gastaut syndrome. The magnetic resonance imaging saggital section T2 weighted image showing hypoplasia, kinking, and downward displacement of the splenium of corpus callosum. Also note atrophy of the cerebellum and the vermis.
Fig. 3 Electroencephalography (longitudinal bipolar montage) showed diffuse background slowing associated with prolonged bursts of high voltage, rhythmic 2 to 2.5 per second spike-wave and polyspike-wave complexes occurring over the right hemisphere with limited projection to the left hemisphere.
Reference
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