Kosin Med J.  2017 Dec;32(2):170-178. 10.7180/kmj.2017.32.2.170.

Retrospective analysis on the clinical efficacy of bevacizumab combined with FOLFOX4 in the first line treatment of metastatic colorectal cancer

• Lee EM
• Park LC
• Lee HS
• Shin SH
• Kim YS

• KMID: 2400260
• DOI: http://doi.org/10.7180/kmj.2017.32.2.170

Abstract

OBJECTIVES
The addition of bevacizumab to standard chemotherapy has been improved survival outcomes in patients with metastatic colorectal cancer. However, the combination of bevacizumab with oxaliplatin-based chemotherapy as first-line treatment showed limited survival benefit. The purpose of this study was to investigate the clinical efficacy and toxicity of the combination of bevacizumab to oxaliplatin and leucovorin (FOLFOX4) in the first-line treatment of patient with metastatic colorectal cancer.
METHODS
Between December 2004 and September 2009, medical records of patients who were diagnosed with metastatic colorectal cancer and received the first line chemotherapy with bevacizumab and FOLFOX4, were retrospectively reviewed.
RESULTS
A total of forty patients were analyzed. The median age of the patients was 55 years (range, 33-80), and 55% was male. The patients received a total of 206 cycles of therapy (median 4 cycles per patient; range 1 - 15 cycles). Of these 40 patients, none achieved complete response (CR) and 15 achieved a partial response (PR), for the overall response rate (ORR) 37.5% (95% CI, 22.5-52.5). Median progression free survival (PFS) was 6.9 months (95% CI, 3.4-10.5) and median overall survival (OS) was 22.6 months (95% CI, 17.3-27.8The most common grade 3 or 4 hematologic toxicity and non-hematologic toxicity were neutropenia (10.0%) and diarrhea (10.0%), respectively. Two patients experienced gastrointestinal perforation.
CONCLUSIONS
In this study, the combination bevacizumab with FOLFOX4 was associated with favorable OS, but did not showed favorable PFS and ORR.

Keyword

Bevacizumab; Colorectal cancer; FOLFOX

MeSH Terms

Bevacizumab*
Colorectal Neoplasms*
Diarrhea
Disease-Free Survival
Drug Therapy
Humans
Leucovorin
Male
Medical Records
Neutropenia
Retrospective Studies*
Treatment Outcome*
Bevacizumab
Leucovorin

Figure

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  Fig. 1. Survival curves by the Kaplan–Meier method.

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