Asia Pac Allergy.  2011 Oct;1(3):145-151. 10.5415/apallergy.2011.1.3.145.

Association of house dust mite-specific IgE with asthma control, medications and household pets

• Albano PM
• Ramos JD

• KMID: 2397433
• DOI: http://doi.org/10.5415/apallergy.2011.1.3.145

Abstract

BACKGROUND
Evidence is conflicting regarding the effectiveness of creating a low-allergen environment or reducing allergen exposure to control asthma exacerbations.
OBJECTIVE
This study determined the association of house dust mite (HDM)-specific IgE levels with asthma symptom control, selected medications, family history of allergic disease, and exposure to second-hand smoke and household pets.
METHODS
Serum samples from 102 doctor-diagnosed allergic asthma patients and 100 non-atopic controls were subjected to enzyme-linked immunosorbent assay using the HDM species Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df), and Blomia tropicalis (Bt) allergens. Point-biserial correlation coefficient, Pearson R correlation, and logistic regression analyses were used to determine association of HDM-specific IgE levels with the abovementioned variables.
RESULTS
Of the 102 cases, 38.24%, 47.06%, and 33.33% were sensitized to Bt, Df, and Dp, respectively. Sensitized patients showed greater probability [Bt (OR = 1.21), Df (OR = 1.14), and Dp (OR = 1.35)] to manifest symptoms than those who were not. Obtained p-values [Bt (p = 0.73), Df (p = 0.83), and Dp (p = 0.59)], however, proved that HDM-specific IgE levels had no significant contribution in predicting or explaining occurrence of asthma symptoms. Bt- and Df-specific IgEs showed moderately weak but significant relationship with bambuterol HCl and expectorant, respectively. Patients currently on said medications registered higher HDM-specific IgE levels than those who were not. No significant correlation between IgE levels and family history of allergic disease or with exposure to second-hand smoke was seen. Dp-specific IgE levels of patients exposed to household pets were significantly lower compared to those without exposure.
CONCLUSION
This study proves that sensitization to Bt, Df, and Dp allergens is not significantly associated with asthma symptoms and control. Although cases were shown to be sensitized to HDMs, their current medications were at least effective in controlling their asthma symptoms.

Keyword

Dermatophagoides pteronyssinus; Dermatophagoides farinae; Blomia tropicalis; Asthma control; Medications; Household pets

MeSH Terms

Allergens
Asthma*
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Dust*
Enzyme-Linked Immunosorbent Assay
Family Characteristics*
Humans
Immunoglobulin E*
Logistic Models
Pyroglyphidae
Smoke
Allergens
Dust
Immunoglobulin E
Smoke

Reference

1. Davis AM, Kreutzer R, Lipsett M, King G, Shaikh N. Asthma prevalence in Hispanic and Asian American ethnic subgroups: results from the California Healthy Kids Survey. Pediatrics. 2006. 118:e363–e370.

2. Szalai C, Ungvári I, Pelyhe L, Tölgyesi G, Falus A. Asthma from a pharmacogenomic point of view. Br J Pharmacol. 2008. 153:1602–1614.

3. Eysink PE, ter Riet G, Aalberse RC, van Aalderen WM, Roos CM, van der Zee JS, Bindels PJ. Accuracy of specific IgE in the prediction of asthma: development of a scoring formula for general practice. Br J Gen Pract. 2005. 55:125–131.

4. Douglass JA, O'Hehir RE. 1. Diagnosis, treatment and prevention of allergic disease: the basics. Med J Aust. 2006. 185:228–233.

5. Chiou YH, Yuo CY, Wang LY, Huang SP. Detection of cross-reactivity for atopic immunoglobulin E against multiple allergens. Clin Diagn Lab Immunol. 2003. 10:229–232.

6. Peters JL, Suglia SF, Platts-Mills TA, Hosen J, Gold DR, Wright RJ. Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS. J Allergy Clin Immunol. 2009. 123:1041–1046.

7. Gent JF, Belanger K, Triche EW, Bracken MB, Beckett WS, Leaderer BP. Association of pediatric asthma severity with exposure to common household dust allergens. Environ Res. 2009. 109:768–774.

8. Gaffin JM, Phipatanakul W. The role of indoor allergens in the development of asthma. Curr Opin Allergy Clin Immunol. 2009. 9:128–135.

9. Lin YC, Su HJ, Hsiue TR, Lee CH, Chen CW, Guo YL. Levels of house dust mite-specific IgE and cockroach-specific IgE and their association with lower pulmonary function in Taiwanese children. Chest. 2002. 121:347–353.

10. Ramos JD, Castillo MP, del Rosario M, Gapay MA, Go TP, Kamantigue EG. Allergenicity and cross-reactivity of 3 house dust mite species among Filipino allergic patients. Philipp J Sci. 2007. 136:139–146.

11. Ohrui T, Funayama T, Sekizawa K, Yamaya M, Sasaki H. Effects of inhaled beclomethasone dipropionate on serum IgE levels and clinical symptoms in atopic asthma. Clin Exp Allergy. 1999. 29:357–361.

12. Harrison TW, Oborne J, Newton S, Tattersfield AE. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet. 2004. 363:271–275.

13. Henderson LL, Larson JB, Gleich GJ. Effect of corticosteroids on seasonal increases in IgE antibody. J Allergy Clin Immunol. 1973. 52:352–357.

14. Settipane GA, Pudupakkam RK, McGowan JH. Corticosteroid effect on immunoglobulins. J Allergy Clin Immunol. 1978. 62:162–166.

15. Zieg G, Lack G, Harbeck RJ, Gelfand EW, Leung DY. In vivo effects of glucocorticoids on IgE production. J Allergy Clin Immunol. 1994. 94:222–230.

16. Stelmach I, Bobrowska-Korzeniowska M, Majak P, Stelmach W, Kuna P. The effect of montelukast and different doses of budesonide on IgE serum levels and clinical parameters in children with newly diagnosed asthma. Pulm Pharmacol Ther. 2005. 18:374–380.

17. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008. 9:3.

18. Scola AM, Loxham M, Charlton SJ, Peachell PT. The long-acting β-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol. 2009. 158:267–276.

19. Yamakawa Y, Ohtsuka Y, Ohtani K, Fujii T, Nagata S, Yamashiro Y, Shimizu T. Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy. Drugs R D. 2010. 10:147–154.

20. Miller CW, Krishnaswamy N, Johnston C, Krishnaswamy G. Severe asthma and the omalizumab option. Clin Mol Allergy. 2008. 6:4.

21. Holgate S, Casale T, Wenzel S, Bousquet J, Deniz Y, Reisner C. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol. 2005. 115:459–465.

22. Acevedo N, Sánchez J, Erler A, Mercado D, Briza P, Kennedy M, Fernandez A, Gutierrez M, Chua KY, Cheong N, Jiménez S, Puerta L, Caraballo L. IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1. Allergy. 2009. 64:1635–1643.

23. Schwindt CD, Tjoa T, Floro JN, McLaren C, Delfino RJ. Association of atopy to asthma severity and medication use in children. J Asthma. 2006. 43:439–446.

24. Glasgow NJ, Ponsonby AL, Kemp A, Tovey E, van Asperen P, McKay K, Forbes S. Feather bedding and childhood asthma associated with house dust mite sensitisation: a randomised controlled trial. Arch Dis Child. 2011. 96:541–547.

25. Diette GB, McCormack MC, Hansel NN, Breysse PN, Matsui EC. Environmental issues in managing asthma. Respir Care. 2008. 53:602–617.

26. Sarinho EC, Mariano J, Sarinho SW, Medeiros D, Rizzo JA, Almerinda RS, Solé D. Sensitisation to aeroallergens among asthmatic and non-asthmatic adolescents living in a poor region in the Northeast of Brazil. Allergol Immunopathol (Madr). 2009. 37:239–243.

27. Kondo N, Matsui E, Nishimura A, Kaneko H. Pharmacogenetics of asthma in children. Allergy Asthma Immunol Res. 2010. 2:14–19.

28. Szalai C, Ungvári I, Pelyhe L, Tölgyesi G, Falus A. Asthma from a pharmacogenomic point of view. Br J Pharmacol. 2008. 153:1602–1614.

29. Kerkhof M, Wijga AH, Brunekreef B, Smit HA, de Jongste JC, Aalberse RC, Hoekstra MO, Gerritsen J, Postma DS. Effects of pets on asthma development up to 8 years of age: the PIAMA study. Allergy. 2009. 64:1202–1208.

30. Polosa R, Russo C, Caponnetto P, Bertino G, Sarvà M, Antic T, Mancuso S, Al-Delaimy WK. Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study. Respir Res. 2011. 12:16.

31. Miyake Y, Miyamoto S, Ohya Y, Sasaki S, Matsunaga I, Yoshida T, Hirota Y, Oda H. Osaka Maternal and Child Health Study Group. Relationship between active and passive smoking and total serum IgE levels in Japanese women: baseline data from the Osaka Maternal and Child Health Study. Int Arch Allergy Immunol. 2004. 135:221–228.

32. Hesselmar B, Aberg N, Aberg B, Eriksson B, Björkstén B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy. 1999. 29:611–617.

33. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet. 2001. 357:752–756.