Asia Pac Allergy.  2015 Jan;5(1):51-54. 10.5415/apallergy.2015.5.1.51.

Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation

  • 1Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
  • 2Professor of Respiratory Medicine, Allergy and Immunology, Monash University, Melbourne, Victoria 3145, Australia.


Oral platelet aggregation inhibitors are widely used for the treatment and prevention of cardiovascular diseases, including coronary stent thrombosis. Premature discontinuation following percutaneous coronary intervention would pose a grave risk of in-stent thrombosis, acute myocardial infarction and eventual death. Although they share the same mechanism of adenosine diphosphate P2Y12 platelet receptor inhibition, they belong to either the chemical class of thienopyridines (clopidogrel, prasugrel, and ticlopidine) or cyclopentyl-triazolo-pyrimidines (ticagrelor and cangrelor). This case describes the first documented cross-reactive hypersensitivity of clopidogrel towards both its fellow thienopyridine, prasugrel, as well as the structurally dissimilar ticagrelor, and its subsequent successful desensitisation.


Platelet aggregation inhibitors; Hypersensitivity; Cross reactions; Desensitization, immunologic
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