Allergy Asthma Respir Dis.  2017 Mar;5(2):73-78. 10.4168/aard.2017.5.2.73.

Serum periostin levels and squamous cell carcinoma-related antigen levels in children with atopic dermatitis

• Choi WH
• Park TY
• Kim SY
• Yu R
• Ban JE
• Yang S
• Hwang IT
• Baek HS

• KMID: 2392377
• DOI: http://doi.org/10.4168/aard.2017.5.2.73

Abstract

PURPOSE
It was found that periostin and squamous cell carcinoma-related antigens (SCCAs) were strongly interleukin-13-inducible gene products. This study measures the serum periostin and SCCA levels in children suffering from atopic dermatitis (AD) and to evaluate the association between the severity of AD and their values.
METHODS
Seventy AD children aged 1 month to 10 years were included in our study. Subjects were characterized as having atopic eczema (AE; n=55) or non-AE (NAE; n=15) by atopic sensitization. Serum SCCA and periostin levels were measured.
RESULTS
The serum periostin levels were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 80.47 ng/mL [75.06-85.93 ng/mL] vs. 67.45 ng/mL [59.99-75.64] ng/mL, P=0.020). The serum concentrations of both SCCA1 and SCCA2 were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 1.401 [1.198-1.643] ng/mL vs. 0.969 [0.723-1.268] ng/mL, P=0.039 for SCCA1) (1.178 [0.974-1.455] ng/mL vs. 0.711 [0.540-0.994] ng/mL, P=0.025 for SCCA2). The serum periostin levels were significantly correlated with disease severity and with peripheral blood eosinophil counts. The SCCA levels were not significantly correlated with disease severity. Both SCCA1 and SCCA2 were significantly correlated with serum periostin levels and blood eosinophil counts.
CONCLUSION
Serum periostin levels may be significantly correlated with disease severity and blood eosinophil counts in children with AD. Serum SCCA levels can be significantly correlated with serum periostin levels and blood eosinophil counts in children with AD.

Keyword

Atopic dermatitis; Periostin; Squamous cell carcinoma-related antigens; Child

MeSH Terms

Child*
Dermatitis, Atopic*
Eosinophils
Epithelial Cells*
Humans

Figure

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  Fig. 1. Serum periostin levels were significantly higher in children with atopic eczema (AE) than in children with nonatopic eczema (NAE).

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  Fig. 2. Serum concentrations of both SCCA1 (A) and SCCA 2 (B) were significantly higher in children with atopic eczema (AE) than in children with nonatopic eczema (NAE). SCCA, squamous cell carcinoma antigen.

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