J Korean Assoc Oral Maxillofac Surg.  2017 Aug;43(4):272-275. 10.5125/jkaoms.2017.43.4.272.

A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report

• Viviano M
• Addamo A
• Cocca S

• KMID: 2391359
• DOI: http://doi.org/10.5125/jkaoms.2017.43.4.272

Abstract

Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.

Keyword

Bisphosphonate-associated osteonecrosis of the jaw; Sepsis; Necrotizing fasciitis; Jaw fractures

MeSH Terms

Bisphosphonate-Associated Osteonecrosis of the Jaw*
Bone Resorption
Diphosphonates
Fasciitis, Necrotizing
Hypercalcemia
Inflammation
Jaw Fractures
Mandible
Multiple Myeloma
Osteolysis
Osteoporosis
Sepsis
Shock, Septic
Diphosphonates