Clin Psychopharmacol Neurosci.  2017 Aug;15(3):285-287. 10.9758/cpn.2017.15.3.285.

Aripiprazole-induced Tardive Dyskinesia in 13 Years Old Girl Successfully Treated with Biperiden: A Case Report

  • 1Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy.,
  • 2Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.


In the last years second-generation antipsychotics are increasingly prescribed in the pediatric population for the treatment of several psychiatric disorders. Among the long term adverse effects, extrapyramidal symptoms (EPS) are less reported compared to first-generation antipsychotics. Tardive dyskinesia (TD) is a iatrogenic rare syndrome characterized by persistent slow writhing and sudden involuntary movements mainly involving the oral-buccal-lingual area with masticatory movements. We report a young girl with mood disorders accompanied by mild intellectual disability and behavioral problems who had TD after treatment with Aripiprazole, which responded to Biperiden therapy.


Antipsychotics; Drug side effects; Tardive dyskineisa; Movement disorders; Pediatrics
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