Clin Psychopharmacol Neurosci.  2017 Aug;15(3):243-247. 10.9758/cpn.2017.15.3.243.

Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment

  • 1Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Toon, Japan.
  • 2Department of Neuropsychiatry, Zaidan Niihama Hospital, Niihama, Japan.


OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil.
Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil.
There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083).
Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment.


Lewy body dementia; Cholinesterase inhibitors; Raven's Colored Progressive Matrices; Visual spatial processing
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