Korean J Vet Res.  2017 Jun;57(2):105-111. 10.14405/kjvr.2017.57.2.105.

Comparative in vivo biodistributions of nanoparticles and polymers of ¹⁷⁷lutetium-labeled hyaluronic acids in mice during 28 days

Affiliations
  • 1College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • 2College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju 28644, Korea. synam@cbu.ac.kr
  • 3Division of Biosafety Evaluation and Control, Centers for Disease Control & Prevention, Cheongju 28159, Korea.
  • 4Asan Institute for Life Sciences, Asan Medical Center and University of Ulsan, Seoul 05505, Korea.
  • 5College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.

Abstract

Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. ¹â·â·Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.

Keyword

drug delivery system; hyaluronic acid; in vivo biodistribution; nanoparticle; ¹⁷⁷lutetium
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