Korean J Intern Med.  2016 Nov;31(6):1101-1109. 10.3904/kjim.2015.148.

Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012

• Kim YS
• Kim HY
• Ahn HS
• Sohn TS
• Song JY
• Lee YB
• Lee DH
• Lee JI
• Lee TK
• Jeong SC
• Hong M
• Chae HS
• Han K
• Yeo CD

• KMID: 2382860
• DOI: http://doi.org/10.3904/kjim.2015.148

Abstract

BACKGROUND/AIMS
The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtration rates (GFRs) in a Korean general population.
METHODS
We used data obtained during the 2010 to 2012 Korean National Health and Nutrition Examination Survey, a national cross-sectional survey. We analyzed data from subjects for whom spirometric assays and estimated GFRs were of acceptable quality.
RESULTS
A total of 8,809 subjects (3,868 male and 4,941 female) was included. In both males and females with GFR values < 60 mL/min/1.73 m², the linear trends toward the presence of obstructive and restrictive patterns were significant. However, the percent predicted forced vital capacity (FVC) decreased with a decline in the estimated GFR, but only in males (p for trend < 0.0031). Multivariate linear regression analysis showed a decline in the estimated GFR was independently associated with falls in the percent predicted FVC and the forced expiratory volume in 1 second/FVC ratio in both males and females. However, the percent predicted FVC was independently predictive only in males (p = 0.002).
CONCLUSIONS
Impaired pulmonary function was associated with a decline in the estimated GFR. The percent predicted FVC decrease paralleled the decline in estimated GFR in male only. Careful interpretation of pulmonary function test data is required in patients with decreased GFRs or impaired renal function, especially males.

Keyword

Respiratory function tests; Glomerular filtration rate

MeSH Terms

Accidental Falls
Cross-Sectional Studies
Female
Forced Expiratory Volume
Glomerular Filtration Rate*
Humans
Kidney Failure, Chronic
Korea*
Linear Models
Male
Nutrition Surveys*
Prevalence
Respiratory Function Tests*
Transplant Recipients
Vital Capacity