Clin Hypertens.  2015 ;21(1):17. 10.1186/s40885-015-0030-9.

Impaired deformability of circulating erythrocytes obtained from nondiabetic hypertensive patients: investigation by a nickel mesh filtration technique

Affiliations
  • 1Department of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
  • 2BOOCS Clinic, Fukuoka 812-0025, Japan.
  • 3Faculty of Art and Science, Kyushu University, Kasuga Kohen 6-1, Kasuga 816-8580, Japan. maruyama@artsci.kyushu-u.ac.jp
  • 4Institute of Rheological Function of Foods Co., Ltd, Hisayama 811-2501, Japan.

Abstract

INTRODUCTION
Hypertension is associated with microcirculatory disturbance, and erythrocyte deformability is a major determinant of the microcirculation. However, impairment of erythrocyte deformability in hypertensive patients in relation to antihypertensive treatment is unclear. The present study aimed to investigate this impairment in hypertensive patients under treatment using a highly sensitive and quantitative nickel mesh filtration technique.
METHODS
Deformability was evaluated by filterability, defined as the flow rate of a hematocrit-adjusted erythrocyte suspension relative to that of saline under a specific filtration pressure in a pressure-flow curve obtained by continuous filtration. Baseline characteristics of hypertensive patients (n = 101) and age-matched normotensive subjects (n = 14) were obtained from medical records, and diabetic patients were excluded.
RESULTS
Erythrocyte deformability in the hypertensive group was significantly (p = 0.010) lower (87.8 +/- 2.2 %) than that of the normotensive group (89.4 +/- 1.7 %) and inversely proportional (r = -0.303, p = 0.002) to the mean blood pressure (BP) measured on blood sampling for the filtration study. Stepwise multiple regression analysis demonstrated that this impairment was mostly attributable to the mean BP (p = 0.001), whereas current smoking and episodes of stroke or coronary artery disease were not contributors. DISCUSSION: These findings indicate that erythrocyte deformability is impaired in the hypertensive patients, which depends on the current BP control rather than target organ damage.

Keyword

Deformability; Erythrocytes; Filtration; Hypertension

MeSH Terms

Blood Pressure
Coronary Artery Disease
Erythrocyte Deformability
Erythrocytes*
Filtration*
Humans
Hypertension
Medical Records
Microcirculation
Nickel*
Smoke
Smoking
Stroke
Nickel
Smoke
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