Brain Tumor Res Treat.  2017 Apr;5(1):16-23. 10.14791/btrt.2017.5.1.16.

An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea, 2013

Affiliations
  • 1Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
  • 2Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea. astra67@ncc.re.kr
  • 3Department of Neurosurgery, Yeungnam University Hospital, Daegu, Korea.
  • 4Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea. heonyoo@ncc.re.kr

Abstract

BACKGROUND
This report aims to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in the Republic of Korea. We updated the data by analyzing primary brain and CNS tumors diagnosed in 2013 using the data from the national cancer incidence database.
METHODS
Data on primary brain and CNS tumors diagnosed in 2013 were collected from the Korean Central Cancer Registry. Crude and age-standardized rates were calculated in terms of gender, age, and histological type.
RESULTS
A total of 11,827 patients were diagnosed with primary brain and CNS tumors in 2013. Brain and CNS tumors occurred in females more often than in males (female:male, 1.70:1). The most common tumor was meningioma (37.3%). Pituitary tumors (18.0%), gliomas (12.7%), and nerve sheath tumors (12.3%) followed in incidence. Glioblastomas accounted for 41.8% of all gliomas. In children (<19 years), sellar region tumors (pituitary and craniopharyngioma), embryonal/primitive/medulloblastoma, and germ cell tumors were the most common tumors.
CONCLUSION
This study should provide valuable information regarding the primary brain tumor epidemiology in Republic of Korea.

Keyword

Epidemiology; Brain; Central nervous system; Tumors; Registries; Korea

MeSH Terms

Brain
Brain Neoplasms*
Central Nervous System
Child
Epidemiology*
Female
Glioblastoma
Glioma
Humans
Incidence
Korea
Male
Meningioma
Neoplasms, Germ Cell and Embryonal
Nerve Sheath Neoplasms
Pituitary Neoplasms
Registries
Republic of Korea*

Figure

  • Fig. 1 Distribution of primary brain and CNS tumors according to sex and behavior, Republic of Korea, 2013. CNS, central nervous system.

  • Fig. 2 Distribution of all brain and CNS tumors according to topography, Republic of Korea, 2013. CNS, central nervous system.

  • Fig. 3 Distribution of primary brain and CNS tumors according to age for selected histology, Republic of Korea, 2013. CNS, central nervous system.

  • Fig. 4 Distribution of brain and CNS tumors according to the histology, Republic of Korea, 2013. NOS, not otherwise specified; CNS, central nervous system.

  • Fig. 5 Incidence according to sex and histology, Republic of Korea, 2013. NOS, not otherwise specified.

  • Fig. 6 Distribution of primary brain and CNS tumors according to histology in children, Republic of Korea, 2013. CNS, central nervous system; NOS, not otherwise specified.


Cited by  15 articles

Epidemiological Study of Malignant Gliomas in Korea Using Nationwide Dataset from 2007 to 2017
Sang Uk Kim, Stephen Ahn, Jung Eun Lee, Kyung-Do Han, Sang Hyun Park, Seung Ho Yang
J Korean Med Sci. 2021;36(9):e68.    doi: 10.3346/jkms.2021.36.e68.

Change of the Self-care Agency and Quality of Life after Craniotomy among Patients with Brain tumor according to time
Su Youn Lee, Se Na Jung, Su Min Jung, Hyun Jin Cho, Hye Kyung Kim
Asian Oncol Nurs. 2019;19(3):117-125.    doi: 10.5388/aon.2019.19.3.117.

The Clinical Outcome of Hydroxyurea Chemotherapy after Incomplete Resection of Atypical Meningiomas
Jungook Kim, Kyu Hong Kim, Young Zoon Kim
Brain Tumor Res Treat. 2017;5(2):77-86.    doi: 10.14791/btrt.2017.5.2.77.

The Korean Society for Neuro-Oncology (KSNO) Guideline for Glioblastomas: Version 2018.01
Young Zoon Kim, Chae-Yong Kim, Jaejoon Lim, Kyoung Su Sung, Jihae Lee, Hyuk-Jin Oh, Seok-Gu Kang, Shin-Hyuk Kang, Doo-Sik Kong, Sung Hwan Kim, Se-Hyuk Kim, Se Hoon Kim, Yu Jung Kim, Eui Hyun Kim, In Ah Kim, Ho Sung Kim, Tae Hoon Roh, Jae-Sung Park, Hyun Jin Park, Sang Woo Song, Seung Ho Yang, Wan-Soo Yoon, Hong In Yoon, Soon-Tae Lee, Sea-Won Lee, Youn Soo Lee, Chan Woo Wee, Jong Hee Chang, Tae-Young Jung, Hye Lim Jung, Jae Ho Cho, Seung Hong Choi, Hyoung Soo Choi, Je Beom Hong, Do Hoon Lim, Dong-Sup Chung,
Brain Tumor Res Treat. 2019;7(1):1-9.    doi: 10.14791/btrt.2019.7.e25.

Extensive Pachymeningeal Dissemination of Glioblastoma Mimicking Chronic Subdural Hematoma: A Case Report
Jiwook Lee, Mee-Seon Kim, Young Zoon Kim
Brain Tumor Res Treat. 2019;7(1):39-43.    doi: 10.14791/btrt.2019.7.e24.

The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade III Cerebral Gliomas in Adults: Version 2019.01
Young Zoon Kim, Chae-Yong Kim, Jaejoon Lim, Kyoung Su Sung, Jihae Lee, Hyuk-Jin Oh, Seok-Gu Kang, Shin-Hyuk Kang, Doo-Sik Kong, Sung Hwan Kim, Se-Hyuk Kim, Se Hoon Kim, Yu Jung Kim, Eui Hyun Kim, In Ah Kim, Ho Sung Kim, Tae Hoon Roh, Jae-Sung Park, Hyun Jin Park, Sang Woo Song, Seung Ho Yang, Wan-Soo Yoon, Hong In Yoon, Soon-Tae Lee, Sea-Won Lee, Youn Soo Lee, Chan Woo Wee, Jong Hee Chang, Tae-Young Jung, Hye Lim Jung, Jae Ho Cho, Seung Hong Choi, Hyoung Soo Choi, Je Beom Hong, Do Hoon Lim, Dong-Sup Chung,
Brain Tumor Res Treat. 2019;7(2):63-73.    doi: 10.14791/btrt.2019.7.e42.

The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01
Young Zoon Kim, Chae-Yong Kim, Chan Woo Wee, Tae Hoon Roh, Je Beom Hong, Hyuk-Jin Oh, Seok-Gu Kang, Shin-Hyuk Kang, Doo-Sik Kong, Sung Hwan Kim, Se-Hyuk Kim, Se Hoon Kim, Yu Jung Kim, Eui Hyun Kim, In Ah Kim, Ho Sung Kim, Jae-Sung Park, Hyun Jin Park, Sang Woo Song, Kyoung Su Sung, Seung Ho Yang, Wan-Soo Yoon, Hong In Yoon, Jihae Lee, Soon-Tae Lee, Sea-Won Lee, Youn Soo Lee, Jaejoon Lim, Jong Hee Chang, Tae-Young Jung, Hye Lim Jung, Jae Ho Cho, Seung Hong Choi, Hyoung Soo Choi, Do Hoon Lim, Dong-Sup Chung,
Brain Tumor Res Treat. 2019;7(2):74-84.    doi: 10.14791/btrt.2019.7.e43.

Prognostic Evaluation of Neurological Assessment of the Neuro-Oncology Scale in Glioblastoma Patients
Jiwook Lee, Sung Hyun Park, Young Zoon Kim
Brain Tumor Res Treat. 2018;6(1):22-30.    doi: 10.14791/btrt.2018.6.e1.

Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae
Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim
Cancer Res Treat. 2021;53(4):983-990.    doi: 10.4143/crt.2020.1052.

A Nationwide, Population-Based Epidemiology Study of Primary Central Nervous System Tumors in Korea, 2007–2016: A Comparison with United States Data
Ho Kang, Sang Woo Song, Johyun Ha, Young-Joo Won, Chul-Kee Park, Heon Yoo, Kyu-Won Jung
Cancer Res Treat. 2021;53(2):355-366.    doi: 10.4143/crt.2020.847.

The Role of Postoperative Radiotherapy in Intracranial Solitary Fibrous Tumor/Hemangiopericytoma: A Multi-institutional Retrospective Study (KROG 18-11)
Joo Ho Lee, Seung Hyuck Jeon, Chul-Kee Park, Sung-Hye Park, Hong In Yoon, Jong Hee Chang, Chang-Ok Suh, Su Jeong Kang, Do Hoon Lim, In Ah Kim, Jin Hee Kim, Jung Ho Im, Sung-Hwan Kim, Chan Woo Wee, Il Han Kim
Cancer Res Treat. 2022;54(1):65-74.    doi: 10.4143/crt.2021.142.

Intracranial Germ Cell Tumor in the Molecular Era
Ji Hoon Phi, Kyu-Chang Wang, Seung-Ki Kim
J Korean Neurosurg Soc. 2018;61(3):333-342.    doi: 10.3340/jkns.2018.0056.

Newly-Diagnosed, Histologically-Confirmed Central Nervous System Tumours in a Regional Hospital in Hong Kong : An Epidemiological Study of a 21-Year Period
Zhexi He, Sui-To Wong, Kwong-Yui Yam
J Korean Neurosurg Soc. 2020;63(1):119-135.    doi: 10.3340/jkns.2018.0209.

Hypo-trimethylation of Histone H3 Lysine 4 and Hyper-tri/dimethylation of Histone H3 Lysine 27 as Epigenetic Markers of Poor Prognosis in Patients with Primary Central Nervous System Lymphoma
Hoon Gi Kim, Minseok S. Kim, Young Sam Lee, Eun Hee Lee, Dae Cheol Kim, Sung-Hun Lee, Young Zoon Kim
Cancer Res Treat. 2022;54(3):690-708.    doi: 10.4143/crt.2021.1121.

Current Immunotherapeutic Approaches for Malignant Gliomas
Myung-Hoon Han, Choong Hyun Kim
Brain Tumor Res Treat. 2022;10(1):1-11.    doi: 10.14791/btrt.2022.10.e25.


Reference

1. Fritz A, Percy C, Jack A, et al. International classification of diseases for oncology. 3rd ed. Geneva: World Health Organizatiol;2000.
2. Bauchet L, Rigau V, Mathieu-Daudé H, et al. French brain tumor data bank: methodology and first results on 10,000 cases. J Neurooncol. 2007; 84:189–199.
Article
3. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014; 16:Suppl 4. iv1–iv63.
Article
4. Kaneko S, Nomura K, Yoshimura T, Yamaguchi N. Trend of brain tumor incidence by histological subtypes in Japan: estimation from the Brain Tumor Registry of Japan, 1973-1993. J Neurooncol. 2002; 60:61–69.
5. Shin HR, Won YJ, Jung KW, et al. Nationwide cancer incidence in Korea, 1999~2001; first result using the national cancer incidence database. Cancer Res Treat. 2005; 37:325–331.
Article
6. Lee CH, Jung KW, Yoo H, Park S, Lee SH. Epidemiology of primary brain and central nervous system tumors in Korea. J Korean Neurosurg Soc. 2010; 48:145–152.
Article
7. Jung KW, Ha J, Lee SH, Won YJ, Yoo H. An updated nationwide epidemiology of primary brain tumors in republic of Korea. Brain Tumor Res Treat. 2013; 1:16–23.
Article
8. Committee of Brain Tumor Registry of Japan. Report of Brain Tumor Registry of Japan (1969-1996). Neurol Med Chir (Tokyo). 2003; 43 Suppl:i–vii. 1–111.
9. Hoffman S, Propp JM, McCarthy BJ. Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol. 2006; 8:27–37.
Article
10. Johannesen TB, Angell-Andersen E, Tretli S, Langmark F, Lote K. Trends in incidence of brain and central nervous system tumors in Norway, 1970-1999. Neuroepidemiology. 2004; 23:101–109.
Article
11. Wöhrer A, Waldhör T, Heinzl H, et al. The Austrian Brain Tumour Registry: a cooperative way to establish a population-based brain tumour registry. J Neurooncol. 2009; 95:401–411.
Article
12. Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975-2013. National Cancer Institute;Accessed January 30, 2016. at http://seer.cancer.gov/csr/1975_2013/.
13. International Agency for Research on Cancer. Annual report of national cancer registration. Cancer incidence in 2005 and survival for 1993-2005. Accessed September 10, 2008. at http://www.iarc.fr/.
14. Segi M. Cancer mortality for selected sites in 24 countries (1950-1957). Sendai: Tohoku University School of Medicine;1960.
15. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. Accessed January 28, 2016. at http://www.globocan.iarc.fr.
Full Text Links
  • BTRT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr