Ann Surg Treat Res.  2017 Mar;92(3):136-142. 10.4174/astr.2017.92.3.136.

Laparoscopic cholecystectomy under spinal-epidural anesthesia vs. general anaesthesia: a prospective randomised study

Affiliations
  • 1Department of General Surgery, Lutfiye Nuri Burat State Hospital, Istanbul, Turkey. surgeont73@hotmail.com
  • 2Department of Anesthesiology and Reanimation, Lutfiye Nuri Burat Goverment Hospital, Istanbul, Turkey.
  • 3Department of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
  • 4Department of General Surgery, Haseki Training and Research Hospital, Istanbul, Turkey.
  • 5Department of General Surgery, Cerrahpasa Medicine Faculty, Istanbul University, Istanbul, Turkey.
  • 6Department of General Surgery, Haydapasa Numune Training and Research Hospital, Istanbul, Turkey.

Abstract

PURPOSE
Laparoscopic cholecystectomy (LC) is usually performed under the general anesthesia (GA). Aim of the study is to investigate the availability, safety and side effects of combined spinal/epidural anesthesia (CSEA) and comparison it with GA for LC.
METHODS
Forty-nine patients who have a LC plan were included into the study. The patients were randomly divided into GA (n = 25) and CSEA (n = 24) groups. Intraoperative and postoperative adverse events, postoperative pain levels were compared between groups.
RESULTS
Anesthesia procedures and surgeries for all patients were successfully completed. After the organization of pneumoperitoneum in CSEA group, 3 patients suffered from shoulder pain (12.5%) and 4 patients suffered from abdominal discomfort (16.6%). All these complaints were recovered with IV fentanyl administration. Only 1 patient developed hypotension which is recovered with fluid replacement and no need to use vasopressor treatment. Postoperative shoulder pain was significantly less observed in CSEA group (25% vs. 60%). Incidence of postoperative nausea and vomiting (PONV) was less observed in CSEA group but not statistically significant (4.2% vs. 20%). In the group of CSEA, 3 patients suffered from urinary retention (12.5%) and 2 patients suffered from spinal headache (8.3%). All postoperative pain parameters except 6th hour, were less observed in CSEA group, less VAS scores and less need to analgesic treatment in CSEA group comparing with GA group.
CONCLUSION
CSEA can be used safely for laparoscopic cholecystectomies. Less postoperative surgical field pain, shoulder pain and PONV are the advantages of CSEA compared to GA.

Keyword

Laparoscopic cholecystectomy; General anesthesia; Epidural anesthesia; Spinal anesthesia

MeSH Terms

Anesthesia*
Anesthesia, Epidural
Anesthesia, General
Anesthesia, Spinal
Cholecystectomy, Laparoscopic*
Fentanyl
Headache
Humans
Hypotension
Incidence
Pain, Postoperative
Pneumoperitoneum
Postoperative Nausea and Vomiting
Prospective Studies*
Shoulder Pain
Urinary Retention
Fentanyl

Figure

  • Fig. 1 Flowchart diagram of the study.


Reference

1. Duncan CB, Riall TS. Evidence-based current surgical practice: calculous gallbladder disease. J Gastrointest Surg. 2012; 16:2011–2025. PMID: 22986769.
Article
2. Johnson A. Laparoscopic surgery. Lancet. 1997; 349:631–635. PMID: 9057744.
Article
3. Liu SY, Leighton T, Davis I, Klein S, Lippmann M, Bongard F. Prospective analysis of cardiopulmonary responses to laparoscopic cholecystectomy. J Laparoendosc Surg. 1991; 1:241–246. PMID: 1834277.
Article
4. Kazama T, Ikeda K, Kato T, Kikura M. Carbon dioxide output in laparoscopic cholecystectomy. Br J Anaesth. 1996; 76:530–535. PMID: 8652326.
Article
5. Wittgen CM, Andrus CH, Fitzgerald SD, Baudendistel LJ, Dahms TE, Kaminski DL. Analysis of the hemodynamic and ventilatory effects of laparoscopic cholecystectomy. Arch Surg. 1991; 126:997–1000. PMID: 1830738.
Article
6. Pursnani KG, Bazza Y, Calleja M, Mughal MM. Laparoscopic cholecystectomy under epidural anesthesia in patients with chronic respiratory disease. Surg Endosc. 1998; 12:1082–1084. PMID: 9685547.
Article
7. Gramatica L Jr, Brasesco OE, Mercado Luna A, Martinessi V, Panebianco G, Labaque F, et al. Laparoscopic cholecystectomy performed under regional anesthesia in patients with chronic obstructive pulmonary disease. Surg Endosc. 2002; 16:472–475. PMID: 11928031.
Article
8. Tiwari S, Chauhan A, Chaterjee P, Alam MT. Laparoscopic cholecystectomy under spinal anaesthesia: a prospective, randomised study. J Minim Access Surg. 2013; 9:65–71. PMID: 23741111.
9. Hajong R, Khariong PD, Baruah AJ, Anand M, Khongwar D. Laparoscopic cholecystectomy under epidural anesthesia: a feasibility study. N Am J Med Sci. 2014; 6:566–569. PMID: 25535604.
Article
10. Das W, Bhattacharya S, Ghosh S, Saha S, Mallik S, Pal S. Comparison between general anesthesia and spinal anesthesia in attenuation of stress response in laparoscopic cholecystectomy: a randomized prospective trial. Saudi J Anaesth. 2015; 9:184–188. PMID: 25829908.
Article
11. Tzovaras G, Fafoulakis F, Pratsas K, Georgopoulou S, Stamatiou G, Hatzitheofilou C. Spinal vs general anesthesia for laparoscopic cholecystectomy: interim analysis of a controlled randomized trial. Arch Surg. 2008; 143:497–501. PMID: 18490561.
12. Singh RK, Saini AM, Goel N, Bisht D, Seth A. Major laparoscopic surgery under regional anesthesia: A prospective feasibility study. Med J Armed Forces India. 2015; 71:126–131. PMID: 25859073.
Article
13. van Zundert AA, Stultiens G, Jakimowicz JJ, Peek D, van der Ham WG, Korsten HH, et al. Laparoscopic cholecystectomy under segmental thoracic spinal anaesthesia: a feasibility study. Br J Anaesth. 2007; 98:682–686. PMID: 17371777.
Article
14. Hamad MA, El-Khattary OA. Laparoscopic cholecystectomy under spinal anesthesia with nitrous oxide pneumoperitoneum: a feasibility study. Surg Endosc. 2003; 17:1426–1428. PMID: 12802665.
Article
15. V K, Pujari VS, R SM, Hiremath BV, Bevinaguddaiah Y. Laparoscopic cholecystectomy under spinal anaesthesia vs. general anaesthesia: a prospective randomised study. J Clin Diagn Res. 2014; 8:NC01–NC04.
Article
16. Kar M, Kar JK, Debnath B. Experience of laparoscopic cholecystectomy under spinal anesthesia with low-pressure pneumoperitoneum: prospective study of 300 cases. Saudi J Gastroenterol. 2011; 17:203–207. PMID: 21546725.
17. Tsai HW, Chen YJ, Ho CM, Hseu SS, Chao KC, Tsai SK, et al. Maneuvers to decrease laparoscopy-induced shoulder and upper abdominal pain: a randomized controlled study. Arch Surg. 2011; 146:1360–1366. PMID: 22184293.
18. Lal P, Philips P, Saxena KN, Kajla RK, Chander J, Ramteke VK. Laparoscopic total extraperitoneal (TEP) inguinal hernia repair under epidural anesthesia: a detailed evaluation. Surg Endosc. 2007; 21:595–601. PMID: 17180283.
Article
19. Gurusamy KS, Samraj K, Davidson BR. Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy. Cochrane Database Syst Rev. 2009; (2):CD006930. PMID: 19370662.
Article
20. Toptas M, Uzman S, Isitemiz I, Uludag Yanaral T, Akkoc I, Bican G. A comparison of the effects of hyperbaric and isobaric bupivacaine spinal anesthesia on hemodynamics and heart rate variability. Turk J Med Sci. 2014; 44:224–231. PMID: 25566589.
21. Gutt CN, Oniu T, Mehrabi A, Schemmer P, Kashfi A, Kraus T, et al. Circulatory and respiratory complications of carbon dioxide insufflation. Dig Surg. 2004; 21:95–105. PMID: 15010588.
Article
22. Cunningham AJ. Anesthetic implications of laparoscopic surgery. Yale J Biol Med. 1998; 71:551–578. PMID: 10604786.
23. Dexter SP, Vucevic M, Gibson J, McMahon MJ. Hemodynamic consequences of high- and low-pressure capnoperitoneum during laparoscopic cholecystectomy. Surg Endosc. 1999; 13:376–381. PMID: 10094751.
Article
24. Imbelloni LE. Spinal anesthesia for laparoscopic cholecystectomy: thoracic vs. lumbar technique. Saudi J Anaesth. 2014; 8:477–483. PMID: 25422604.
Article
25. Imbelloni LE, Sant'anna R, Fornasari M, Fialho JC. Laparoscopic cholecystectomy under spinal anesthesia: comparative study between conventional-dose and low-dose hyperbaric bupivacaine. Local Reg Anesth. 2011; 4:41–46. PMID: 22915892.
Article
26. Bablekos GD, Michaelides SA, Analitis A, Charalabopoulos KA. Effects of laparoscopic cholecystectomy on lung function: a systematic review. World J Gastroenterol. 2014; 20:17603–17617. PMID: 25516676.
Article
27. Mehta PJ, Chavda HR, Wadhwana AP, Porecha MM. Comparative analysis of spinal versus general anesthesia for laparoscopic cholecystectomy: a controlled, prospective, randomized trial. Anesth Essays Res. 2010; 4:91–95. PMID: 25885237.
Article
28. Bessa SS, Katri KM, Abdel-Salam WN, El-Kayal el-SA, Tawfik TA. Spinal versus general anesthesia for day-case laparoscopic cholecystectomy: a prospective randomized study. J Laparoendosc Adv Surg Tech A. 2012; 22:550–555. PMID: 22686181.
Article
29. Sinha R, Gurwara AK, Gupta SC. Laparoscopic surgery using spinal anesthesia. JSLS. 2008; 12:133–138. PMID: 18435884.
30. Lee JH, Huh J, Kim DK, Gil JR, Min SW, Han SS. Laparoscopic cholecystectomy under epidural anesthesia: a clinical feasibility study. Korean J Anesthesiol. 2010; 59:383–388. PMID: 21253374.
Article
Full Text Links
  • ASTR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr