Yonsei Med J.  2016 May;57(3):776-783. 10.3349/ymj.2016.57.3.776.

Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis

Affiliations
  • 1Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. zd05lcyxcmt@sina.com
  • 2Department of Infant Health Care, Xiacheng Traditional Chinese Medical Hospital, Hangzhou, China.

Abstract

PURPOSE
Many epidemiological studies have investigated environmental risk factors for the development of acoustic neuroma. However, these results are controversial. We conducted a meta-analysis of case-control studies to identify any potential relationship between history of noise exposure, smoking, allergic diseases, and risk of acoustic neuroma.
MATERIALS AND METHODS
We searched PubMed to identify relevant articles. Two researchers evaluated the eligibility and extracted the data independently.
RESULTS
Eleven case-control studies were included in our meta-analysis. Acoustic neuroma was found to be associated with leisure noise exposure [odds ratio (OR)=1.33, 95% confidence interval (CI): 1.05-1.68], but not with occupational noise exposure and ever noise exposure (OR=1.20, 95% CI: 0.84-1.72 and OR=1.15, 95% CI: 0.80-1.65). The OR of acoustic neuroma for ever (versus never) smoking was 0.53 (95% CI: 0.30-0.94), while the subgroup analysis indicated ORs of 0.95 (95% CI: 0.81-1.10) and 0.49 (95% CI: 0.41-0.59) for ex-smoker and current smoker respectively. The ORs for asthma, eczema, and seasonal rhinitis were 0.98 (95% CI: 0.80-1.18), 0.91 (95% CI: 0.76-1.09), and 1.52 (95% CI: 0.90-2.54), respectively.
CONCLUSION
Our meta-analysis is suggestive of an elevated risk of acoustic neuroma among individuals who were ever exposed to leisure noise, but not to occupational noise. Our study also indicated a lower acoustic neuroma risk among ever and current cigarette smokers than never smokers, while there was no significant relationship for ex-smokers. No significant associations were found between acoustic neuroma and history of any allergic diseases, such as asthma, eczema, and seasonal rhinitis.

Keyword

Noise; smoking; allergy; acoustic neuroma; meta-analysis

MeSH Terms

Adult
Asthma/complications
Environmental Exposure/*adverse effects
Female
Humans
Hypersensitivity
*Leisure Activities
Neuroma, Acoustic/epidemiology/*etiology
Noise/*adverse effects
Occupational Exposure/adverse effects
Risk Factors
Smoking/adverse effects
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