Yonsei Med J.  2016 May;57(3):674-680. 10.3349/ymj.2016.57.3.674.

Visceral Fat Mass Has Stronger Associations with Diabetes and Prediabetes than Other Anthropometric Obesity Indicators among Korean Adults

Affiliations
  • 1Ajou University School of Medicine, Suwon, Korea.
  • 2Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. djkim@ajou.ac.kr
  • 3Cardiovascular and Metabolic Disease Etiology Research Center, Ajou University School of Medicine, Suwon, Korea.

Abstract

PURPOSE
This study determined which obesity measurement correlates the best with diabetes and prediabetes.
MATERIALS AND METHODS
This cross-sectional study enrolled 1603 subjects (611 men, 992 women; age 30-64 years) at the Cardiovascular and Metabolic Diseases Etiology Research Center. Body mass index, waist circumference, waist-height ratio, waist-hip ratio, waist-thigh ratio, and visceral fat were used as measures of obesity. Visceral fat was acquired using dual-energy X-ray absorptiometry (DXA). The prevalences of diabetes and prediabetes were defined using the criteria in the American Diabetes Association 2015 guidelines.
RESULTS
After adjusting for age and other potential confounding factors, participants with a visceral fat mass in the upper 10th percentile had a higher odds ratio (OR) for diabetes and prediabetes than the upper 10th percentile of other adiposity indices [men, OR=15.9, 95% confidence interval (CI)=6.4-39.2; women, OR=6.9, 95% CI=3.5-13.7]. Visceral fat mass also had the highest area under the curve with diabetes and prediabetes in both men (0.69, 95% CI=0.64-0.73) and women (0.70, 95% CI=0.67-0.74) compared to other anthropometric measurements of obesity.
CONCLUSION
Visceral fat mass measured using DXA is an indicator of diabetes or prediabetes, due to its ability to differentiate between abdominal visceral and subcutaneous fat.

Keyword

Diabetes mellitus; obesity; visceral fat

MeSH Terms

Absorptiometry, Photon
*Adiposity
Adult
Anthropometry
Asian Continental Ancestry Group/*statistics & numerical data
Biomarkers/blood
Body Mass Index
Cross-Sectional Studies
Diabetes Mellitus/*ethnology
Female
Humans
*Intra-Abdominal Fat
Male
Middle Aged
Obesity/complications/*ethnology
Odds Ratio
Prediabetic State/*ethnology
Prevalence
Prospective Studies
Republic of Korea/epidemiology
Waist Circumference
Biomarkers

Figure

  • Fig. 1 The risk of diabetes or prediabetes for 10 percentile of adiposity indices in men (A) and women (B). Adjusted for age, smoking status, alcohol consumption, physical activity, menopause status (only women), and education levels.

  • Fig. 2 Receiver operating characteristic curve of adiposity indices for identifying diabetes or prediabetes.


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