Yonsei Med J.  2016 May;57(3):614-620. 10.3349/ymj.2016.57.3.614.

Association between the Red Cell Distribution Width and Vasospastic Angina in Korean Patients

• Jung MH
• Shin DI
• Choi IJ
• Seo SM
• Choi S
• Park MW
• Kim PJ
• Baek SH
• Seung KB

• KMID: 2374079
• DOI: http://doi.org/10.3349/ymj.2016.57.3.614

Abstract

PURPOSE
The association between the red cell distribution width (RDW) and vasospastic angina (VSA) has not been elucidated. We investigated the association of the RDW with the incidence and angiographic subtypes of VSA in Korean patients.
MATERIALS AND METHODS
A total of 460 patients who underwent intracoronary ergonovine provocation tests were consecutively enrolled and classified into two groups: the VSA group (n=147, 32.0%) and non-VSA group (n=313, 68.0%). The subjects were classified into 3 subgroups (tertiles) according to the baseline level of RDW assessed before the angiographic provocation test.
RESULTS
The VSA group had a higher RDW than the non-VSA group (12.9±0.8% vs. 12.5±0.7%, p=0.013). The high RDW level demonstrated an independent association with the high incidence of VSA [second tertile: hazard ratio (HR) 1.96 (1.13-2.83), third tertile: HR 2.33 (1.22-3.47), all p<0.001]. Moreover, the highest RDW tertile level had a significant association with the prevalence of the mixed-type coronary spasm [HR 1.29 (1.03-1.59), p=0.037].
CONCLUSION
The high level of RDW was significantly associated with the prevalence of VSA and the high-risk angiographic subtype of coronary spasm, suggesting that a proactive clinical investigation for VSA could be valuable in Korean patients with an elevated RDW.

Keyword

Angina pectoris; variant; coronary vasospasm; erythrocyte indices

MeSH Terms

Aged
Aged, 80 and over
Angina Pectoris/*blood/ethnology
Coronary Angiography/methods
Coronary Vasospasm/*blood/ethnology
Erythrocyte Indices/*physiology
Female
Humans
Incidence
Male
Middle Aged
Prevalence
Proportional Hazards Models
Republic of Korea/epidemiology

Figure

• 

  Fig. 1 Incidence of VSA according to the baseline RDW. The baseline RDW demonstrates a significant association with the incidence of VSA. VSA, vasospastic angina; RDW, red cell distribution width.

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