Ann Lab Med.  2016 Nov;36(6):590-594. 10.3343/alm.2016.36.6.590.

Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis

• Yang HS
• Hur M
• Kim H
• Magrini L
• Marino R
• Di Somma S
• GREAT Network

• KMID: 2373598
• DOI: http://doi.org/10.3343/alm.2016.36.6.590

Abstract

Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown. We explored whether sST2 serum concentration reflects either systolic or diastolic dysfunction as measured by Doppler echocardiography. In a total of 127 patients with sepsis, correlations between sST2 and blood pressure, left ventricular (LV) ejection fraction, LV diastolic filling (ratio of early transmitral flow velocity to early diastolic mitral annulus velocity), and resting pulmonary arterial pressure were evaluated. Correlations between sST2 and other sepsis biomarkers (high-sensitivity C-reactive protein [hs-CRP] and procalcitonin) were also examined. sST2 showed a moderate correlation with mean arterial pressure (r=-0.3499) but no correlation with LV ejection fraction, diastolic filling, or resting pulmonary hypertension. It showed moderate correlations with hs-CRP and procalcitonin (r=0.2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis.

Keyword

sST2; Sepsis; Echocardiography; Left ventricular ejection fraction; Diastolic filling

MeSH Terms

Aged
Aged, 80 and over
Biomarkers/blood
Blood Pressure/physiology
C-Reactive Protein/analysis
Calcitonin/blood
Echocardiography, Doppler
Female
Humans
Interleukin-1 Receptor-Like 1 Protein/*blood
Male
Middle Aged
Sepsis/diagnostic imaging/metabolism/*physiopathology
Ventricular Function, Left/physiology
Biomarkers
Calcitonin
C-Reactive Protein
Interleukin-1 Receptor-Like 1 Protein

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