J Gastric Cancer.  2010 Jun;10(2):55-62.

Clinicopathologic Characteristics in Node-negative Gastric Cancer Patients According to the Presence of Lymphatic Invasion

• Choi JY
• Ha TK
• Kwon SJ

Abstract

PURPOSE
We evaluated the clinicopathological charicterics and prognostic impacts of lymphatic vessel invasion in gastric cancer without lymph node involvement.
MATERIALS AND METHODS
Among 1,795 patients who underwent gastric surgery with gastric cancer at the department of surgery, Hanyang university college of medicine from June 1992 to March 2009, we retrospectively evaluated 890 patients with lymph node negative gastric cancer.
RESULTS
The lymphatic vessel invasion correlated significantly with tumor stage, age, tumor size, perineural invasion and operation method. The survival rates were only significantly different between the patients with and without lymphatic vessel invasion in patients with stage Ia (P=0.036). Univariate and multivariate analysis demonstrated that blood vessel invasion and preoperative serum CEA level were significant factor influencing the survival rate in lymph node negative gastric cancer patients with lymphatic invasion.
CONCLUSIONS
In patients with lymph node negative gastric cancer, the survival rate is significantly lower in those with lymphatic vessel invasion than in those without. Especially, in patients with stage Ia gastric cancer, the survival rates is significantly different between those with and those without lymphatic vessel invasion. Blood vessel invasion and preoperative serum CEA level is an adverse prognostic indicator in patients with stage Ia gastric cancer with lymphatic invasion. Thus we should consider further adjuvant therapies in case of need and need to show more concern to identify gastric cancer patients early at risk for recurrence.

Keyword

Stomach neoplasms; Lymphatic invasion; Prognosis

MeSH Terms

Blood Vessels
Glycosaminoglycans
Humans
Lymph Nodes
Lymphatic Vessels
Multivariate Analysis
Prognosis
Recurrence
Retrospective Studies
Stomach Neoplasms
Survival Rate
Glycosaminoglycans

Figure

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  Fig. 1 Survival rate of lymph node negative gastric cancer patients according to the presence of lymphatic invasion(LN- = lymph node negative; ly+ = lymphatic invasion positive; ly- = lymphatic invasion negative).

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  Fig. 2 Survival rate of lymph node negative stage Ia gastric cancer patients according to the presence of lymphatic invasion (ly+ = lymphatic invasion positive; ly- = lymphatic invasion negative).

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