J Gastric Cancer.  2012 Dec;12(4):258-261.

Ewing's Sarcoma of the Stomach; Rare Case of Ewing's Sarcoma and Suggestion of New Treatment Strategy

• Kim HS
• Kim S
• Min YD
• Kee KH
• Hong R

Abstract

Ewing's sarcoma is a neoplasm of the undifferenciated small round cells, which generally affects the bone and deep soft tissues of children and adolescents. We present a case of gastric Ewing's sarcoma; a 35-year-old female who had no symptoms. While she was at a routine medical checkup, a protruding mass in her gastric antrum was incidentally found on esophagogastroduodenoscopy. Endoscopic ultrasonogram showed a submucosal mass on the same lesion and a laparosopic wedge resection was done. Pathologic gross findings showed a granular grape appearance tissue and histoloigc examination revealed a small round cell tumor with CD 99 immunoexpression positive. In general, a combined modality therapy for Ewing's sarcoma such as surgical resection with chemotherapy, is accepted as an effective method. However, this patient had no adjuvant chemotherapy after surgery and she has no recurrence for eleven months.

Keyword

Ewing's sarcoma; Combined modality therapy; Chemotherapy

MeSH Terms

Adolescent
Chemotherapy, Adjuvant
Child
Combined Modality Therapy
Endoscopy, Digestive System
Female
Humans
Pyloric Antrum
Recurrence
Sarcoma, Ewing
Vitis

Figure

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  Fig. 1 (A) Endoscopic view. A 2.5 cm sized protruding mass with central depression and erythematous change is noted in the anterior wall of proximal antrum just below angle. (B) Intraoperative laparoscopic view. Granular grape appearance mass is noted on laparoscopic view.

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  Fig. 2 Relativley monomorphic small cells with round or oval nuclei with well defined nuclear membrane (H&E, ×200).

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  Fig. 3 (A) Immunohistology. CD99 (+) (×400). (B) Immunohistology. Synaptophysin (+) (×400). (C) Immunohistology. Chromogranin A (-) (×400). (D) Immunohistology. Cytokeratin (-) (×400). (E) Immunohistology. Desmin (-) (×400).

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