J Gastric Cancer.  2014 Mar;14(1):54-57.

Gastric Carcinoma with Bone Marrow Metastasis: A Case Series

Affiliations
  • 1Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital, Ankara, Turkey. a.siyar@hotmail.com

Abstract

Gastric cancer is a major cause of cancer-related mortality. At the time of diagnosis, majority of the patients usually have unresectable or metastatic disease. The most common sites of metastases are the liver and the peritoneum, but in the advanced stages, there may be metastases to any region of the body. Bone marrow is an important metastatic site for solid tumors, and the prognosis in such cases is poor. In gastric cancer cases, bone marrow metastasis is usually observed in younger patients and in those with poorly differentiated tumors. Prognosis is worsened owing to the poor histomorphology as well as the occurrence of pancytopenia. The effect of standard chemotherapy is unknown, as survival is limited to a few weeks. This report aimed to evaluate 5 gastric cancer patients with bone marrow metastases to emphasize the importance of this condition.

Keyword

Stomach neoplasms; Bone marrow metastasis; Poor prognosis

MeSH Terms

Bone Marrow*
Diagnosis
Drug Therapy
Humans
Liver
Mortality
Neoplasm Metastasis*
Pancytopenia
Peritoneum
Prognosis
Stomach Neoplasms

Reference

1. Ministry of Health, Public Health Agency Turkey. T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu [Internet]. Ankara: Ministry of Health, Public Health Agency Turkey;2008. Available from: http://www.kanser.gov.tr.
2. Anner RM, Drewinko B. Frequency and significance of bone marrow involvement by metastatic solid tumors. Cancer. 1977; 39:1337–1344.
Article
3. Kiliçkap S, Erman M, Dinçer M, Aksoy S, Harputluoglu H, Yalçin S. Bone marrow metastasis of solid tumors: clinicopathological evaluation of 73 cases. Turk J Cancer. 2007; 37:85–88.
4. Mehdi SR, Bhatt ML. Metastasis of solid tumors in bone marrow: a study from northern India. Indian J Hematol Blood Transfus. 2011; 27(2):93–95.
Article
5. Mohanty SK, Dash S. Bone marrow metastasis in solid tumors. Indian J Pathol Microbiol. 2003; 46:613–616.
6. Tasleem RA, Chowdhary ND, Kadri SM, Chowdhary QA. Metastasis of solid tumours in bone marrow: a study from Kashmir, India. J Clin Pathol. 2003; 56:803.
Article
7. Frisch B, Bartl R, Burkhardt R. Bone marrow biopsy in clinical medicine: an overview. Haematologia (Budap). 1982; 15:245–285.
8. Penchansky L. Bone marrow biopsy in the metastatic work-up of solid tumors in children. Cancer. 1984; 54:1447–1448.
Article
9. Wong KF, Chan JK, Ma SK. Solid tumour with initial presentation in the bone marrow--a clinicopathologic study of 25 adult cases. Hematol Oncol. 1993; 11:35–42.
Article
10. Clifton JA, Philipp RJ, Ludovic E, Fowler WM. Bone marrow and carcinoma of the prostate. Am J Med Sci. 1952; 224:121–130.
Article
11. Finklestein JZ, Ekert H, Isaacs H Jr, Higgins G. Bone marrow metastases in children with solid tumors. Am J Dis Child. 1970; 119:49–52.
Article
12. Kim HS, Yi SY, Jun HJ, Lee J, Park JO, Park YS, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology. 2007; 73:192–197.
Article
13. Kusumoto H, Haraguchi M, Nozuka Y, Oda Y, Tsuneyoshi M, Iguchi H. Characteristic features of disseminated carcinomatosis of the bone marrow due to gastric cancer: the pathogenesis of bone destruction. Oncol Rep. 2006; 16:735–740.
Article
14. Kwon JY, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Cancer Res Treat. 2011; 43:244–249.
Article
15. Ahn JB, Ha TK, Kwon SJ. Bone metastasis in gastric cancer patients. J Gastric Cancer. 2011; 11:38–45.
Article
16. Nishidoi H, Koga S. Clinicopathological study of gastric cancer with bone metastasis. Gan To Kagaku Ryoho. 1987; 14:1717–1722.
17. Kong JH, Lee J, Yi CA, Park SH, Park JO, Park YS, et al. Lung metastases in metastatic gastric cancer: pattern of lung metastases and clinical outcome. Gastric Cancer. 2012; 15:292–298.
Article
18. Ajani JA, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, et al. V-325 Study Group. Clinical benefit with docetaxel plus fluorouracil and cisplatin compared with cisplatin and fluorouracil in a phase III trial of advanced gastric or gastroesophageal cancer adenocarcinoma: the V-325 Study Group. J Clin Oncol. 2007; 25:3205–3209.
Article
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