Ann Occup Environ Med.  2016 ;28(1):21. 10.1186/s40557-016-0108-1.

Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report

• Lee JW
• Myong JP
• Choi YJ
• Lee S
• Jo BS
• Koo JW

• KMID: 2370901
• DOI: http://doi.org/10.1186/s40557-016-0108-1

Abstract

BACKGROUND
An association between silica exposure and autoimmune diseases including rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis has been made.
CASE PRESENTATION
A 56-year-old male presented with silicosis and had an occupational history of precious metal processing for 30 years and a 30 pack-year smoking history. The patient was diagnosed with pneumoconiosis and received compensation. No other complications were reported for pneumoconiosis. The patient suddenly presented with a non-specific headache for several days and microscopic hematuria was identified upon examination in the outpatient clinic. Following several weeks, the patient presented with aggravated dyspnea and hemoptysis, and his Modification of Diet in Renal Disease estimated glomerular filtration rate indicated acute kidney injury. Diagnostic analysis revealed perinuclear ANCA-associated microscopic polyangiitis (p-ANCA-associated MPA).
CONCLUSION
Exposure to silica dust was likely one of the cause of p-ANCA-associated MPA. Possible pathogenic mechanisms of autoimmune diseases in silicotics and emphasis of the necessity for early diagnosis are discussed.

Keyword

Keywords; Occupational exposure; Silicon dioxide; Silicosis; Autoimmune disease

MeSH Terms

Acute Kidney Injury
Ambulatory Care Facilities
Arthritis, Rheumatoid
Autoimmune Diseases
Compensation and Redress
Cytoplasm*
Diagnosis*
Diet
Dust
Dyspnea
Early Diagnosis
Glomerular Filtration Rate
Headache
Hematuria
Hemoptysis
Humans
Lupus Erythematosus, Systemic
Male
Microscopic Polyangiitis*
Middle Aged
Occupational Exposure
Pneumoconiosis
Scleroderma, Systemic
Silicon Dioxide
Silicosis
Smoke
Smoking
Vasculitis
Dust
Silicon Dioxide
Smoke