Clin Psychopharmacol Neurosci.  2017 Feb;15(1):35-39. 10.9758/cpn.2017.15.1.35.

Evaluation of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Fetal Cord Blood of Depressed Mothers

Affiliations
  • 1Department of Psychiatry, AfÅŸin State Hospital, KahramanmaraÅŸ Sütçüİmam University, KahramanmaraÅŸ, Turkey. dr.akif@gmail.com
  • 2Department of Psychiatry, Faculty of Medicine, KahramanmaraÅŸ Sütçüİmam University, KahramanmaraÅŸ, Turkey.
  • 3Department of Obstetry, Faculty of Medicine, KahramanmaraÅŸ Sütçüİmam University, KahramanmaraÅŸ, Turkey.
  • 4Department of Biochemistry, Faculty of Medicine, KahramanmaraÅŸ Sütçüİmam University, KahramanmaraÅŸ, Turkey.

Abstract

OBJECTIVE: The umbilical cord consists of two arteries and one vein and it functions in the transport between the maternal and fetal circulation. Biochemical analysis of fetal cord blood (FCB) during delivery could be beneficial in terms of understanding the fetal environment. In this study, we aimed to investigate oxidative parameters like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels in FCB during delivery.
METHODS
We collected FCB samples during caesarean section. Our study included 33 depressed mothers and 37 healthy controls. We investigated MDA, SOD, and CAT levels in FCB samples.
RESULTS
We found no significant difference between groups in terms of MDA (p=0.625), SOD (p=0.940), and CAT (p=0.413) levels.
CONCLUSION
Our study reveals probable protective effects of the placenta from oxidative stress. Future studies should include larger samples.

Keyword

Fetal cord blood; Pregnancy; Depression; Malondialdehyde; Supeoxide dismutase; Catalase
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