J Bacteriol Virol.  2016 Dec;46(4):303-306. 10.4167/jbv.2016.46.4.303.

An Update on Gut Microbiota and Infant's Health

• Manzoor Z
• Koh YS

• KMID: 2366877
• DOI: http://doi.org/10.4167/jbv.2016.46.4.303

Abstract

Childhood malnutrition is a global problem and one of the leading cause of stunted growth, and responsible for the death of millions of children every year. Although extensive efforts have been made to promote healthy growth but results are not satisfactory and infant's health remains a challenge. Previously, it was demonstrated that undernourished children have disrupted normal pattern of intestinal microbiota and led to a proposal that it might be involved in impaired postnatal growth. Recently, various research groups focused on Malawian population and proved the role of intestinal microbiota in the stunted growth of children. In addition, one group showed the role of sialylated bovine milk oligosaccharides in promoting microbiota-dependent growth in malnourished children. Moreover, it was also revealed that Clostridium symbiosum and Ruminococcus gnavus might be used as therapeutic agent for ameliorating growth abnormalities in malnourished children. The current article summarizes the recent advancement in identifying interventions regarding health promotion of malnourished children.

Keyword

Microbiota; Stunted growth; Malnutrition; Infant's health

MeSH Terms

Child
Clostridium symbiosum
Gastrointestinal Microbiome*
Growth Disorders
Health Promotion
Humans
Malnutrition
Microbiota
Milk
Oligosaccharides
Ruminococcus
Oligosaccharides

Reference

1). Hizli S, Abaci A, Buyukgebiz B, Buyukgebiz A. Nutritional stunting. Pediatr Endocrinol Rev. 2007; 4:186–95.

2). Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, et al. Maternal and child undernutrition: consequences for adult health and human capital. Lancet. 2008; 371:340–57.

3). Charbonneau MR, O'Donnell D, Blanton LV, Totten SM, Davis JC, Barratt MJ, et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell. 2016; 164:859–71.

4). Subramanian S, Huq S, Yatsunenko T, Haque R, Mahfuz M, Alam MA, et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature. 2014; 510:417–21.

5). Huda MN, Lewis Z, Kalanetra KM, Rashid M, Ahmad SM, Raqib R, et al. Stool microbiota and vaccine responses of infants. Pediatrics. 2014; 134:e362–72.

6). Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, et al. Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J Physiol Gastrointest Liver Physiol. 2008; 295:G1025–34.

7). Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature. 2011; 469:543–7.

8). Bartz S, Mody A, Hornik C, Bain J, Muehlbauer M, Kiyimba T, et al. Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J Clin Endocrinol Metab. 2014; 99:2128–37.

9). Thomas T, Burguera B, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Riggs BL, et al. Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. Bone. 2001; 29:114–20.

10). Gaayeb L, Sarr JB, Cames C, Pincon C, Hanon JB, Ndiath MO, et al. Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal. Am J Trop Med Hyg. 2014; 90:566–73.

11). Waber DP, Bryce CP, Girard JM, Zichlin M, Fitzmaurice GM, Galler JR. Impaired IQ and academic skills in adults who experienced moderate to severe infantile malnutrition: a 40-year study. Nutr Neurosci. 2014; 17:58–64.

12). Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013; 382:427–51.

13). Dewey KG. The challenge of meeting nutrient needs of infants and young children during the period of complementary feeding: an evolutionary perspective. J Nutr. 2013; 143:2050–4.

14). Keusch GT, Denno DM, Black RE, Duggan C, Guerrant RL, Lavery JV, et al. Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences. Clin Infect Dis. 2014; 59(Suppl 4):S207–12.

15). Richard SA, McCormick BJ, Miller MA, Caulfield LE, Checkley W. Modeling environmental influences on child growth in the MAL-ED cohort study: opportunities and challenges. Clin Infect Dis. 2014; 59(Suppl 4):S255–60.

16). Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science. 2016; 351.

17). Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Transl Med. 2015; 7:276ra24.

18). Schwarzer M, Makki K, Storelli G, Machuca-Gayet I, Srutkova D, Hermanova P, et al. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science. 2016; 351:854–7.