Blood Res.  2016 Dec;51(4):279-281. 10.5045/br.2016.51.4.279.

The first case of acute myeloid leukemia with solitary t(6;7)(p21.3;p22) passenger translocation that developed at relapse after allogeneic hematopoietic stem cell transplantation in a patient with a normal karyotype at the initial diagnosis

• Park SH
• Lee EY
• Shin HJ

• KMID: 2364320
• DOI: http://doi.org/10.5045/br.2016.51.4.279

Abstract

No abstract available.

MeSH Terms

Diagnosis*
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Karyotype*
Leukemia, Myeloid, Acute*
Recurrence*

Figure

• 

  Fig. 1 Bone marrow aspiration (A, Wright stain, ×1,000), myeloperoxidase cytochemical stain (B, ×1,000), biopsy (C, H&E stain, ×1,000), and karyotype results (D) performed for our patient at the time of relapse. The patient's bone marrow aspiration shows infiltration of leukemic blasts using myeloperoxidase cytochemical stain positivity (A and B). The biopsy section also shows normocellularity with infiltration of leukemic blasts (C). His karyotype result obtained at relapse showed 46,XY, t(6;7)(p21.3;p22)[4]/46,XY[26] (the two breakpoint lesions are indicated with a black arrow), indicating the emergence of a solitary t(6;7)(p21.3;p22) passenger translocation with a frequency of 13.3% at relapse (D).

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