J Korean Med Sci.  2016 Mar;31(3):371-375. 10.3346/jkms.2016.31.3.371.

Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea

• Kwon T
• Moon KH
• Yang SH
• Roh MC
• Lee SH
• Kim JW
• Kim IK
• Roh KH
• Park S

• KMID: 2363496
• DOI: http://doi.org/10.3346/jkms.2016.31.3.371

Abstract

Further understanding of male human papillomavirus (HPV) infection is necessary to prevent infection in men, as well as transmission to women. In our current study, we investigated patterns of HPV infection and genotype distributions in male genital warts using the Anyplex II HPV28 Detection kit. We reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in Ulsan, Korea, for the treatment of genital warts between April 2014 and January 2015. All patients underwent HPV genotyping. The prevalence and characteristics of HPV infection were analyzed, and the patterns of HPV infection according to age were assessed. Among the study patients, 13 (16.3%) were negative for HPV infection, 46 (57.3%) were infected with low-risk HPV, and 21 (26.3%) were infected with high-risk HPV. Patients with multiple HPV infection were more likely to have high-risk HPV infection (P = 0.001). The prevalence of HPV infection was much higher in samples obtained by tissue excision due to a definite lesion (P = 0.001). There were no differences in high-risk HPV infection (P = 0.459), multiple HPV infection (P = 0.185), and recurrence at diagnosis (P = 0.178) according to age. HPV-6 and HPV-11 were the most common type overall (39.7% and 13.8%, respectively). HPV-16 and HPV-18 were the most common high-risk infections (both 3.4%). HPV infection is not only commonly encountered in male genital warts, but is also accompanied by high-risk HPV and multiple infections.

Keyword

Human Papillomavirus; Oncogenic; Genotype; Human Papillomavirus-6; Human Papillomavirus-11; Condyloma Acuminata; Men, Ulsan

MeSH Terms

Adult
Condylomata Acuminata/epidemiology/*pathology/virology
DNA, Viral/genetics/metabolism
Genotype
Human papillomavirus 11/*genetics/isolation & purification
Human papillomavirus 16/genetics/isolation & purification
Human papillomavirus 18/genetics/isolation & purification
Human papillomavirus 6/*genetics/isolation & purification
Humans
Male
Middle Aged
Prevalence
Real-Time Polymerase Chain Reaction
Republic of Korea/epidemiology
Retrospective Studies
Risk Factors
DNA, Viral