Int J Thyroidol.  2016 Nov;9(2):127-130. 10.11106/ijt.2016.9.2.127.

Effects of Thyroid Stimulating Hormone on Bone Metabolism

• Cho SW

• KMID: 2362347
• DOI: http://doi.org/10.11106/ijt.2016.9.2.127

Abstract

Bone is a dynamic tissue undergoing life-long remodeling, a process of bone resorption by osteoclast and bone formation by osteoblast, regulated by diverse hormones including estrogen. Recently, several pituitary hormones have been identified as a modulator of this process. Here, we reviewed the role of thyroid stimulating hormone signaling per se in bone metabolism.

Keyword

Thyroid stimulating hormone; Bone resorption; Bone formation; Bone remodeling

MeSH Terms

Bone Remodeling
Bone Resorption
Estrogens
Metabolism*
Osteoblasts
Osteoclasts
Osteogenesis
Pituitary Hormones
Thyroid Gland*
Thyrotropin*
Estrogens
Pituitary Hormones
Thyrotropin

Figure

• 

  Fig. 1. Hypothalamus-pituitary-thyroid-bone axis. The hypo-thalamic neurons secrete thyrotropin releasing hormone (TRH) is secreted by hypothalamic neurons and carried down to the pituitary gland where it releases thyroid stimulating hormone (TSH). TSH reaches thyroid glands and stimulates the productions of thyroxin (T4) and triiodothyronine (T3) by binding to TSH receptor (TSHR). T3 exerts its actions on bone mainly through thyroid hormone receptor α (TRα). TSH can directly act on bone by binding to TSHR. Increased levels of circulating T3 can get negative feedback loop by inhibiting TRH and TSH releases.

Reference

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