Ann Surg Treat Res.  2016 Dec;91(6):323-326. 10.4174/astr.2016.91.6.323.

Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT

• Park HL
• Yoo IR
• Kim SH
• Lee S

• KMID: 2360393
• DOI: http://doi.org/10.4174/astr.2016.91.6.323

Abstract

The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). She underwent total parathyroidectomy with video-assisted thoracoscopic surgery on an anterior mediastinal mass. Anterior mediastinal parathyroid adenoma in MEN1 patients is rare. Precise localization of an ectopic parathyroid gland with Tc-99m sestamibi SPECT/CT can lead to successful treatment of hyperparathyroidism. This is the first reported case in the literature of mediastinal parathyroid adenoma in MEN1 patient visualized by Tc-99m sestamibi SPECT/CT.

Keyword

Multiple endocrine neoplasia type 1; Parathyroid neoplasms; Single-photon emission-computed tomography; Technetium-99m sestamibi

MeSH Terms

Female
Humans
Hyperparathyroidism
Male
Middle Aged
Multiple Endocrine Neoplasia Type 1*
Multiple Endocrine Neoplasia*
Parathyroid Glands
Parathyroid Neoplasms*
Parathyroidectomy
Radionuclide Imaging
Siblings
Thoracic Surgery, Video-Assisted
Tomography, Emission-Computed, Single-Photon