Korean J Gastroenterol.  2016 Sep;68(3):127-131. 10.4166/kjg.2016.68.3.127.

Current Status of Translational Research on Gastroesophageal Reflux Disease

• Jeong ID
• Park MI

• KMID: 2358713
• DOI: http://doi.org/10.4166/kjg.2016.68.3.127

Abstract

The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extra-esophageal manifestations. The aim of this article is to provide a review of available current translational research on GERD. This review includes acid pocket, ambulatory pH monitoring, impedance pH monitoring, mucosa impedance, and high resolution manometry. This article discusses current translational research on GERD.

Keyword

Gastroesophageal reflux; Esophageal pH monitoring; Impedance

MeSH Terms

Electric Impedance
Esophageal pH Monitoring
Gastroesophageal Reflux*
Hydrogen-Ion Concentration
Incidence
Manometry
Mucous Membrane
Prevalence
Proton Pump Inhibitors
Translational Medical Research*
Proton Pump Inhibitors

Reference

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