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Distal Mean Nocturnal Baseline Impedance Predicts Pathological Reflux of Isolated Laryngopharyngeal Reflux Symptoms

Luo HN, Wang CC, Lin YC, Chuang CY, Tsou YA, Fu JC, Yang SS, Chang CS, Lien HC

  • KMID: 2541569
  • J Neurogastroenterol Motil.
  • 2023 Apr;29(2):174-182.
  • doi: 10.5056/jnm22049
Background/Aims Diagnosis of isolated laryngopharyngeal reflux symptoms (ILPRS), ie, without concomitant typical reflux symptoms (CTRS), remains difficult. Mean nocturnal baseline impedance (MNBI) reflects impaired mucosal integrity. We determined whether esophageal MNBI...
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Prevalence of Non-erosive Esophageal Phenotypes in Children: A European Multicenter Study

Blasi E, Stefanelli E, Tambucci R, Salvatore S, Angelis PD, Quitadamo P, Pacchiarotti C, Nardo GD, Crocco F, Felici E, Giorgio V, Staropoli N, Sestito S, Saliakellis E, Borrelli O, Pensabene L

  • KMID: 2541567
  • J Neurogastroenterol Motil.
  • 2023 Apr;29(2):156-165.
  • doi: 10.5056/jnm22115
Background/Aims Since available data on pediatric non-erosive esophageal phenotypes (NEEPs) are scant, we investigated their prevalence and the phenotype-dependent treatment response in these children. Methods Over a 5-year period, children with negative upper...
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Chemoprevention of Barrett’s Esophagus

Song KH

The prevalence of Barrett’s esophagus is increasing in South Korea. Several strategies have been tried to prevent its progression to esophageal adenocarcinoma. It is questionable whether the strategies being tried...
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A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease

Park SH, Lee KN, Lee OY, Choi MG, Kim JH, Sung IK, Jang JY, Park KS, Chun HJ, Kim EY, Lee JK, Jang JS, Kim GH, Hong SJ, Lee YC, Choi SC, Kim HS, Kim TO, Baik GH, Jeon YC

Background/Aims: Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). The aim of this study was to comparatively evaluate the efficacy and safety of esomeprazole...
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Effects of Tegoprazan Versus Esomeprazole on Nighttime Heartburn and Sleep Quality in Gastroesophageal Reflux Disease: A Multicenter Double-blind Randomized Controlled Trial

Kim JS, Seo SI, Kang SH, Lee SK, Kim AR, Park HW, Kim BT, Song GS

  • KMID: 2537940
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):58-64.
  • doi: 10.5056/jnm22104
Background/Aims Patients with gastroesophageal reflux disease (GERD) frequently experience nighttime heartburn and sleep disturbance. Tegoprazan is a new potassium-competitive acid blocker that can rapidly block acid secretion. This study aims to...
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Validation of Pharyngeal Acid Reflux Episodes Using Hypopharyngeal Multichannel Intraluminal Impedance-pH

Chen YY, Wang CC, Lin YC, Kao JY, Chuang CY, Tsou YA, Fu JC, Yang SS, Chang CS, Lien HC

  • KMID: 2537939
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):49-57.
  • doi: 10.5056/jnm22047
Background/Aims Hypopharyngeal multichannel intraluminal impedance-pH (HMII-pH) technology incorporating 2 trans-upper esophageal sphincter impedance channels has been developed to detect pharyngeal reflux. We used the HMII-pH technique to validate the candidate pharyngeal...
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Clinical Characteristics of Patients With Ineffective Esophageal Motility by Chicago Classification Version 4.0 Compared to Chicago Classification Version 3.0

Kurin M, Adil SA, Damjanovska S, Tanner S, Greer K

  • KMID: 2537938
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):38-48.
  • doi: 10.5056/jnm21250
Background/Aims Chicago classification version 4.0 (CCv4.0) of esophageal motility disorders developed a more stringent diagnostic criteria for ineffective esophageal motility (IEM) than version 3.0. We studied the implications of the new...
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Prevalence and Risk Factors of Functional Gastrointestinal Disorders in Infants in Indonesia

Lestari LA, Rizal AN, Damayanti W, Wibowo Y, Ming C, Vandenplas Y

Purpose: Information regarding functional gastrointestinal disorders (FGIDs) in infants is currently lacking in Indonesia. This study aimed to describe the prevalence and risk factors of FGIDs in infants aged 6...
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Treatment of Acid-related Diseases Using Potassium-competitive Acid Blockers

Choi YJ

Proton pump inhibitors (PPIs) have several limitations to their efficacy including insufficient acid suppression, slow onset of action, and variable efficacy among patients due to CYP2C19 metabolism. Potassium-competitive acid blockers...
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Surgical treatment for gastroesophageal reflux disease

Kim JJ

Background: Gastroesophageal reflux disease (GERD) is one of the most common upper gastrointestinal diseases that affects 10% to 20% of the general population worldwide. Current Concepts: Proton pump inhibitors (PPIs), the...
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Clinical Implications of the Gastroesophageal Reflux Disease Questionnaire and Reflux Symptom Index in Patients With Suspected Laryngopharyngeal Reflux Symptoms

Kim YD, Shin CM, Jeong WJ, Kim YJ, Yoon H, Park YS, Kim N, Lee DH

  • KMID: 2534319
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):599-607.
  • doi: 10.5056/jnm21235
Background/Aims To evaluate the usefulness of gastroesophageal reflux disease questionnaire (GerdQ) and reflux symptom index (RSI) for diagnosis of gastroesophageal reflux disease (GERD) in patients with suspected laryngopharyngeal reflux (LPR) symptoms...
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Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index Could Identify Gastroesophageal Reflux Disease but pH-Impedance Metrics Alone Might Not Correlate With Proton Pump Inhibitor Response in Chinese Patients With Typical Reflux Symptoms

Wang D, Duan C, Zhang X, Xu J, Hou X, Xiang X

  • KMID: 2534317
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):580-588.
  • doi: 10.5056/jnm21156
Background/Aims Lyon consensus differentiates acid exposure time (AET) as physiological, borderline, and pathological. Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave index (PSPWi) are believed to increase diagnostic yield...
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Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease

Jandee S, Keeratichananont S, Tack J, Vanuytsel T

  • KMID: 2534312
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):531-539.
  • doi: 10.5056/jnm22082
Manometry, particularly high-resolution manometry is the preferred diagnostic tool used to evaluate esophageal motor function. This investigation is strongly indicated in the setting of dysphagia, but is also useful in...
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Safe implementation of transoral incisionless fundoplication as a new technique in a tertiary care center

Bomman S, Malashanka S, Ghafoor A, Sanders DJ, Irani S, Kozarek RA, Ross A, Hubka M, Krishnamoorthi R

Background/Aims: Transoral incisionless fundoplication (TIF) is an accepted anatomic treatment for gastroesophageal reflux disease in selected patients. In this report, we analyze our institution’s programmatic allocation of resources during the...
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Nissen Fundoplication for the Treatment of Gastroesophageal Reflux After Repair of Esophageal Atresia

Ho IG, Ihn K, Jeon HJ, Lee D, Oh JT, Han SJ

Purpose Gastroesophageal reflux disease (GERD) frequently affects patients with esophageal atresia (EA). GERD is often resistant to medical therapy, and anti-reflux surgery in the form of fundoplication is required. However, there...
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Seronegative Celiac Disease in Patients with Isolated Refractory Dyspepsia and Gastroesophageal Reflux Disease

Tokmak S, Boral B, Gumurdulu Y

Background/aims: To investigate the presence of seronegative celiac disease in patients with isolated refractory dyspepsia and gastroesophageal reflux disease (GERD)-related complaints. Methods: This was a single-center, prospective study performed at a...
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Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis

He M, Wang Q, Yao D, Li J, Bai G

  • KMID: 2528035
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):212-221.
  • doi: 10.5056/jnm21044
Background/Aims The incidence of gastroesophageal reflux disease (GERD) is increasing annually. Studies have suggested that psychosocial disorders may be linked to the development of GERD. However, studies evaluating the association between...
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2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

Jung HK, Tae CH, Song KH, Kang SJ, Park JK, Gong EJ, Shin JE, Lim HC, Lee SK, Jung DH, Choi YJ, Seo SI, Kim JS, Lee JM, Kim BJ, Kang SH, Park CH, Choi SC, Kwon JG, Park KS, Park MI, Lee TH, Kim SY, Cho YS, Lee HH, Jung KW, Kim DH, Moon HS, Choi MY, Lee KJ, The Korean Society of Neurogastroenterology and Motility

Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of...
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Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey

Ogasawara N, Funaki Y, Kasugai K, Ebi M, Tamura Y, Izawa S, Sasaki M

  • KMID: 2528044
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):291-302.
  • doi: 10.5056/jnm21065
Background/Aims Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. Methods This internet-based survey recruited...
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Clinical Practice Guidelines on Pediatric Gastroesophageal Reflux Disease: A Systematic Quality Appraisal of International Guidelines

Harris J, Chorath K, Balar E, Xu K, Naik A, Moreira A, Rajasekaran K

Purpose: While regurgitation is a common and often benign phenomenon in infants and younger children, it can also be a presenting symptom of gastroesophageal reflux disease (GERD). If untreated, GERD...
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