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Usefulness of Endoscopic Hill Grade in Evaluating Children Suspected of Having Gastroesophageal Reflux Disease

Yoo IH, Joo JY, Yang HR

  • KMID: 2514676
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):191-197.
  • doi: 10.5056/jnm20033
Background/Aims This study aim to evaluate the relationship between the Hill grade confirmed by esophagogastroduodenoscopy (EGD) and the degree of gastroesophageal reflux (GER) by 24-hour multichannel intraluminal impedance-pH monitoring (MII-pH) in...
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Characteristics of Symptomatic Belching in Patients With Belching Disorder and Patients Who Exhibit Gastroesophageal Reflux Disease With Belching

Jeong SO, Lee JS, Lee TH, Hong SJ, Cho YS, Park J, Jeon SR, Kim HG, Kim JO

  • KMID: 2514681
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):231-239.
  • doi: 10.5056/jnm20114
Background/Aims Belching disorder (BD) is clinically distinct from gastroesophageal reflux disease (GERD) with belching. Supragastric belching (SGB) is closely associated with reflux episodes. This study investigates belch characteristics in association with...
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Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients

Lin Y, Li Y, Liang M, Tan N, Zhang M, Chen S, Xiao Y

  • KMID: 2510062
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):55-62.
  • doi: 10.5056/jnm19219
Background/Aims There is less acid burden in Chinese gastroesophageal reflux disease (GERD) patients. However, the Lyon consensus proposed a higher threshold of acid exposure time (AET > 6%) for GERD. The...
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Factors of Reflux Episodes With Post-reflux Swallowinduced Peristaltic Wave in Gastroesophageal Reflux Disease

Xu H, Ye B, Ding Y, Wang M, Lin L, Jiang L

  • KMID: 2504006
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):378-383.
  • doi: 10.5056/jnm19115
Background/Aims It is known that post-reflux swallow-induced peristaltic wave (PSPW) index represents the chemical clearance of the esophagus. However, few studies have explored why some reflux episodes could induce PSPW...
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Multichannel Intraluminal Impedance and pH Monitoring: A Step Towards Pediatric Reference Values

Cresi F, Cester EA, Salvatore S, Rose DUD, Ripepi A, Magistà AM, Fontana C, Maggiora E, Coscia A, Francavilla R, Cristofori F

  • KMID: 2504005
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):370-377.
  • doi: 10.5056/jnm19205
Background/Aims Combined multichannel intraluminal impedance and pH monitoring (MII/pH) is considered the most accurate test to detect gastroesophageal reflux (GER), however lacking reference values. We aim to determine reference values...
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Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring

Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, Shimpi R, Gyawali CP, Patel A

  • KMID: 2507111
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):455-462.
  • doi: 10.5056/jnm19142
Background/Aims Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar...
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Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders

Wang YJ, Lang XQ, Wu D, He YQ, Lan CH, Xiao X, Wang B, Zou DW, Wu JM, Zhao YB, Dettmar PW, Chen DF, Yang M

  • KMID: 2500652
  • J Neurogastroenterol Motil.
  • 2020 Jan;26(1):74-84.
  • doi: 10.5056/jnm19032
Background/Aims To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. Methods Overall, 322 patients with different sub-types of GERD and 45 healthy...
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A Review of Making the Modern Diagnosis of Gastrointestinal Reflux Disease: the Lyon Consensus

Kim TO, Jung HK

Gastroesophageal reflux disease (GERD) is diagnosed according to the medical history or in response to proton pump inhibitor therapy. However, the need for further testing is always appropriate. The decisive...
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Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry

Bennett MC, Patel A, Sainani N, Wang D, Sayuk GS, Gyawali CP

  • KMID: 2417382
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):387-394.
  • doi: 10.5056/jnm17126
BACKGROUND/AIMS: Breaks in the peristaltic contour on esophageal high-resolution manometry (HRM) may be associated with bolus retention in the esophagus. We evaluated the relationship between peristaltic breaks and esophageal symptoms,...
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Juice Test for Identification of Nonerosive Reflux Disease in Heartburn Patients

Fernandes , De Oliveira M, Callegari-Jacques SM, Gonçalves GVR, Fornari F

  • KMID: 2413099
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):233-240.
  • doi: 10.5056/jnm17077
BACKGROUND/AIMS: Evaluation of esophageal clearance by orange juice swallowing could be useful to identify different categories of gastroesophageal reflux disease. We determined whether a juice test at the beginning of...
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Pathophysiology of Potassium-competitive Acid Blocker–refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test

Masaoka T, Kameyama H, Yamane T, Yamamoto Y, Takeuchi H, Suzuki H, Kitagawa Y, Kanai T

  • KMID: 2422848
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):577-583.
  • doi: 10.5056/jnm18036
BACKGROUND/AIMS: Potassium-competitive acid blockers are expected to be the next generation of drugs for the treatment of diseases caused by gastric acid. In 2015, vonoprazan fumarate, a novel potassium-competitive acid...
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Gastroesophageal Reflux in Neurologically Impaired Children: What Are the Risk Factors?

Kim S, Koh H, Lee JS

BACKGROUND/AIMS: Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically...
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A Review of Diagnosis of GERD

Jeong ID

The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the accumulation in our understanding on...
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Current Status of Translational Research on Gastroesophageal Reflux Disease

Jeong ID, Park MI

The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of...
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Laryngopharyngeal Reflux in Children with Chronic Otitis Media with Effusion

Górecka-Tuteja A, Jastrzębska I, Składzień J, Fyderek K

  • KMID: 2327950
  • J Neurogastroenterol Motil.
  • 2016 Jul;22(3):452-458.
  • doi: 10.5056/jnm16013
BACKGROUND/AIMS: To evaluate the characteristic properties of laryngopharyngeal reflux (LPR) and gastroesophageal reflux (GER) in children with otitis media with effusion (OME) using 24-hour multichannel intraluminal impedance combined with dual-probe...
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Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett's Esophagus Than in Healthy Controls

Lottrup C, Krarup AL, Gregersen , Ejstrud P, Drewes AM

  • KMID: 2433455
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):630-642.
  • doi: 10.5056/jnm16019
BACKGROUND/AIMS: Impaired esophageal acid clearance may be a contributing factor in the pathogenesis of Barrett’s esophagus. However, few studies have measured acid clearance as such in these patients. In this...
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Evaluation of Gastroesophageal Reflux Disease Using the Bravo Capsule pH System

Lawenko RM, Lee YY

  • KMID: 2379701
  • J Neurogastroenterol Motil.
  • 2016 Jan;22(1):25-30.
  • doi: 10.5056/jnm15151
Gastroesophageal reflux disease (GERD) is a disease predominantly seen in the West but there is a rising trend in Asia. Ambulatory 24-hour catheter-based pH monitoring has been the de facto...
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Is the Impedance Baseline Helpful in the Evaluation of Globus Patients?

Chun YJ, Choi MG, Kim HH, Cho YK, Ku A

  • KMID: 2433478
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):390-397.
  • doi: 10.5056/jnm14129
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) has been suggested to be responsible for 23-68% of globus cases. The impedance baseline (IB) acquired by 24-hour multichannel intraluminal impedance monitoring has been proven...
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Inconsistency in the Diagnosis of Functional Heartburn: Usefulness of Prolonged Wireless pH Monitoring in Patients With Proton Pump Inhibitor Refractory Gastroesophageal Reflux Disease

Penagini R, Sweis R, Mauro A, Domingues , Vales A, Sifrim D

  • KMID: 2381258
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):265-272.
  • doi: 10.5056/jnm14075
BACKGROUND/AIMS: The diagnosis of functional heartburn is important for management, however it stands on fragile pH monitoring variables, ie, acid exposure time varies from day to day and symptoms are...
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Achalasia Previously Diagnosed as Gastroesophageal Reflux Disease by Relying on Esophageal Impedance-pH Monitoring: Use of High-Resolution Esophageal Manometry in Children

Pyun JE, Choi DM, Lee JH, Yoo KH, Shim JO

Gastroesophageal reflux disorder (GERD) is the most common esophageal disorder in children. Achalasia occurs less commonly but has similar symptoms to GERD. A nine-year old boy presented with vomiting, heartburn,...
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