Korean J Anesthesiol.  1978 Dec;11(4):289-293.

A Clinical Experience with Althesin ( CT 1341 ) as an Induction Agent

• Kim CK
• Chung WH

Abstract

Althesin(CT 1341), a new steroid anesthetic, was tried clinically as an induction agent. All 24 patients were in the physical status class 1 by A.S.A. classification. Dosage of althesin given intravenously was 50ul/kg B.W. and the injection speed for the given dose was 15 seconds. The following results were obtained. 1) Induction time was 42+/-19. 7 seconds. 2) No significant changes in pulse rate were found after intravenous injection of althesin. 3) Systolic blood pressure was decreased 8mmHg (p<0.01) after one minute of injection and 11 mmHg (p<0.01) after three minutes and raised to preanesthetic level after five minutes. No significant change was found in diastolic blood pressure. 4) Respiratory rate was increased 3/min. (p<0.05) after three minutes. 5) Minute volume was decreased 170Gml (p<0.01) after one minute and 700ml (p<0.05> after three minutes. 6) As complications, involuntary muscle movement of extremities was observed in two cases and transient apnea in one case.

MeSH Terms

Alfaxalone Alfadolone Mixture*
Apnea
Blood Pressure
Classification
Extremities
Heart Rate
Humans
Injections, Intravenous
Muscle, Smooth
Respiratory Rate
Alfaxalone Alfadolone Mixture