J Korean Diabetes.  2016 Sep;17(3):155-158. 10.4093/jkd.2016.17.3.155.

Sleep and Diabetes

Affiliations
  • 1Sleep Clinic, Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. eunyeon1220.joo@samsung.com

Abstract

Sleep is a physiologic state of decreased metabolism and serves a reparative role, marked by increased glycogen stores and peptide synthesis. Normal sleep is characterized by reduced glucose turnover by the brain and other metabolically active tissues, particularly during non-rapid eye movement sleep. Circadian and sleep-related changes in glucose tolerance occur in normal subjects. Sleep duration has decreased over the last several decades, and with this have come cross-sectional and longitudinal data suggesting a link between short sleep duration and the prevalence of type 2 diabetes. Forced decreased sleep duration in healthy individuals has linked to impaired glucose homeostasis. Moreover, short sleep duration has been associated with obesity. Obstructive sleep apnea syndrome is characterized by diminished or abrogated airflow, which results in intermittent hypoxia and sleep fragmentation. This disorder appears to be associated with impaired glucose tolerance. Thus, the quality and quantity of sleep may have a profound effect on type 2 diabetes; therefore, these relationships should be carefully assessed in primary and endocrinology clinics.

Keyword

Diabetes mellitus; Obstructive sleep apnea; Sleep; Sleep deprivation

MeSH Terms

Anoxia
Brain
Diabetes Mellitus
Endocrinology
Eye Movements
Glucose
Glycogen
Homeostasis
Metabolism
Obesity
Prevalence
Sleep Apnea, Obstructive
Sleep Deprivation
Glucose
Glycogen

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