Ann Dermatol.  2015 Jun;27(3):338-339. 10.5021/ad.2015.27.3.338.

A Pediatric Case of Spitzoid Melanoma with Subsequent Large Lymph Node Metastasis

Affiliations
  • 1Department of Plastic and Reconstructive Surgery, National Hospital Organization, Nagasaki Medical Center, Ohmura, Japan. k.hayashida@nagasaki-mc.com

Abstract

No abstract available.


MeSH Terms

Lymph Nodes*
Melanoma*
Neoplasm Metastasis*

Figure

  • Fig. 1 (A) A 10-mm dome-shaped pigmented nodule on the left lower leg. (B) Histopathology of the skin lesion; Breslow's thickness clearly exceeded 4 mm. No ulceration was present (H&E, ×10). (C) Abundant irregular nests of varying size and shape, and asymmetrical proliferation of enlarged atypical epithelioid and spindle-shaped melanocytes in the deep dermis (H&E, ×20). (D) Atypical epithelioid and spindle-shaped melanocytes with large hyperchromatic pleomorphic nuclei were observed (H&E, ×40).

  • Fig. 2 Magnetic resonance imaging (left panel) and anterior projection images from the positron emission tomography-computed tomography scan (right panel). Note the extensive left inguinal lymph node uptake (arrows). This sentinel lymph node was larger than 7-cm.


Reference

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2. Pol-Rodriquez M, Lee S, Silvers DN, Celebi JT. Influence of age on survival in childhood spitzoid melanomas. Cancer. 2007; 109:1579–1583.
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3. Busam KJ, Murali R, Pulitzer M, McCarthy SW, Thompson JF, Shaw HM, et al. Atypical spitzoid melanocytic tumors with positive sentinel lymph nodes in children and teenagers, and comparison with histologically unambiguous and lethal melanomas. Am J Surg Pathol. 2009; 33:1386–1395.
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