Korean J Anesthesiol.  1985 Jun;18(2):169-175.

Immediate Changes in Serum K+, Ca++ and Na+ Concentration Induced by Suceinylcholine Following d-Tubocurarine and Diazepam Pretreatment

• Hahm SA
• Lee CH

Abstract

The changes in serum electrolytes that follow the administration of succinylcholine have been reported in numerous publications since the first description of hyperkalemia by Klupp et al in 1954. The changes in serum K+, Ca++ and Na+ after administration of succinylcholine, 2mg/kg, were compared in 3groups of 20 patients each to determine the effect of diasepam and d-Tubocurarine pretreatment on the elctrolyte level. Group l received succinylcholine 2mg/kg only; group ll diazepam 0.2mg/kg 3 minutes before succinylcholine; group lll 3mg d-Tubocurarine 3 minutes before succinylcholine. This investigation was limited to the first 10 minutes after induction on sixty, ASA class 1 patients undergoing elective surgical procedure. The results were as follows: 1) A significant increase of serum potassium concentration was observed at 4 minutes and 6 minutes in group l compared to baseline value(p<0.05). 2) Mean peak change ratio in serum potassium was significantly lower in group lll than group l (p<0.05). 3) There was no significant changes in serum concentration in 3 groups. 4) There was no significant changes in serum sodium concentration except for a decrease at 10 minutes in group l(p<0.05).

MeSH Terms

Diazepam*
Electrolytes
Humans
Hyperkalemia
Potassium
Sodium
Succinylcholine
Surgical Procedures, Elective
Tubocurarine*
Diazepam
Electrolytes
Potassium
Sodium
Succinylcholine
Tubocurarine